- MW:588.6 Da
- Appearance:White solid
Etoposide is a Topoisomerase II inhibitor derived from podophyllotoxin. It induces apoptosis, autophagy in various cell lines and has a antitumor property so can be used for treatment of cancer. This reagent suppresses DNA synthesis and blocks specific cell cycles because it helps to break double-strand DNA by generating transient double-stranded breaks in the double helix.
Its antitumor property is explained by activation of tumor suppressor p53 and inhibition of synthesis of oncoprotein Mdm2 and overexpress Mdm2 to promote apoptosis.
• Anti-tumor reagent
• Preparation of drug stock solution in dimethyl sulfoxide (DMSO)
• DNA damage inducer
Not for human therapeutic use or for medicinal purposes. For research applications only.
|Handling||Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation.|
|UN #'S||Not Applicable|
|Packing Group||Not Applicable|