- MW:588.6 Da
- Appearance:White solid
Topoisomerase II inhibitor. Anti-tumor reagent. Widely used apoptosis inducer by FasL. Semisynthetically derived frompodophyllotoxin.
VePesid; Toposar; Lastet; Zuyeyidal; Etoposidum; Etoposido; Eposin
Soluble in DMSO (25 mg/mL)
Desiccated at -20°C
Etoposide (VP-16) is a Topo II (topoisomerase II) inhibitor that is widely used as an apoptosis inducer. Etoposide exhibits antineoplastic and anti-mitotic properties, as well as, inhibits DNA synthesis and induces double-strand and single-strand DNA breaks. Etoposide is cell-cycle dependent and cell-cycle specific to late S and G2 phases, activates p53, resulting in upregulated expression of TRAIL-R2 (DR5) and Bak to overcome TRAIL resistance in Bax-deficient human colon carcinoma cancer cells. Etoposide (VP-16) is an inhibitor of NCoA-3.
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation.
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|Handling||Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation.|
|UN #'S||Not Applicable|
|Packing Group||Not Applicable|