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Fidaxomicin

SKU
F-2425
  • CAS:873857-62-6
  • Formula:C52H74Cl2O18
  • MW:1,058
  • Appearance:White to off-white Powder
  • Purity:>99% by HPLC
Product Name Qty
Fidaxomicin
50 mg
$80.00
Fidaxomicin
100 mg
$142.00
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Description

Fidaxomicin is a recently marketed antibiotic with a confusing history dating back to its original isolation in 1975. Fidaxomicin is the major analogue of a family of macrocyclic lactones, isolated independently by three different groups from cultures belonging to three different genera (Actinoplanes, Dactylosporangium and Micromonospora) known as lipiarmycin A3, tiacumicin B and clostomicin B1, respectively. Fidaxomicin is a narrow spectrum antibiotic with excellent activity against Gram-positive bacteria, notably Clostridium difficile. Fidaxomicin acts in the gastrointestinal tract without undue disruption to gut microflora.

Fidaxomicin is used to treat diarrhea caused by Clostridium difficile.

Isolated from Dactylosporangium aurantiacum.

Additional reading: Fidaxomicin Applications

 

References

• Antibiotic fidaxomicin is an RdRp inhibitor as a potential new therapeutic agent against Zika virus

• Synthesis and Biological Evaluation of Iodinated Fidaxomicin Antibiotics

• First-line Fidaxomicin Use in High-risk Inpatients Reduces Recurrence Rates

• Fidaxomicin for the treatment of Clostridioides difficile in children

• Inhibitory effect of fidaxomicin on biofilm formation in Clostridioides difficile

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Dificid, Dificlir, Lipiarmycin, Tiacumicin B, Difimicin, Clostomicin B1
SKU
F-2425
CAS #
873857-62-6
Chemical Name
[(2R,3S,4S,5S,6R)-6-[[(3E,5E,8S,9E,11S,12R,13E,15E,18S)-12-[(2R,3S,4R,5S)-3,4-dihydroxy-6,6-dimethyl-5-(2-methylpropanoyloxy)oxan-2-yl]oxy-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]meth
Chemical Formula
C52H74Cl2O18
Molecular Weight
1,058
Appearance
White to off-white Powder
Purity
>99% by HPLC
Solubility
Clear colorless solution at 1mg/ml of DMSO; Clear colorless solution at 5 mg/ml of Methanol
Storage Temp
-20ºC
THERAPEUTIC AREA
Infectious Diseases
USE
Fidaxomicin is a narrow spectrum antibiotic, inhibiting bacterial RNA polymerase and demonstrates excellent activity against Gram positive bacteria.
MDL NUMBER
MFCD27976367
INCHI
InChI=1S/C52H74Cl2O18/c1-13-30-22-26(6)33(56)18-16-15-17-31(23-66-51-45(65-12)42(61)44(29(9)67-51)69-49(64)35-32(14-2)36(53)39(58)37(54)38(35)57)48(63)68-34(28(8)55)20-19-25(5)21-27(7)43(30)70-50-41(60)40(59)46(52(10,11)72-50)71-47(62)24(3)4/h15-17,19,21-22,24,28-30,33-34,40-46,50-51,55-61H,13-14,18,20,23H2,1-12H3/b16-15+,25-19+,26-22+,27-21+,31-17+/t28-,29-,30+,33+,34+,40-,41+,42+,43+,44-,45+,46+,50-,51-/m1/s1
SMILES
CC[C@H]1/C=C(/[C@H](C/C=C/C=C(/C(=O)O[C@@H](C/C=C(/C=C(/[C@@H]1O[C@H]2[C@H]([C@H]([C@@H](C(O2)(C)C)OC(=O)C(C)C)O)O)\C)\C)[C@@H](C)O)\CO[C@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)OC(=O)C4=C(C(=C(C(=C4O)Cl)O)Cl)CC)O)OC)O)\C
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Thermal decomposition can lead to release of toxic/corrosive gases and vapors.
GHS PICTOGRAMS
HandlingAvoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Thermal decomposition can lead to release of toxic/corrosive gases and vapors.
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