Fidaxomicin
- CAS:873857-62-6
- Formula:C52H74Cl2O18
- MW:1,058
- Appearance:White to off-white Powder
- Purity:>99% by HPLC

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Description
Fidaxomicin is a recently marketed antibiotic with a confusing history dating back to its original isolation in 1975. Fidaxomicin is the major analogue of a family of macrocyclic lactones, isolated independently by three different groups from cultures belonging to three different genera (Actinoplanes, Dactylosporangium and Micromonospora) known as lipiarmycin A3, tiacumicin B and clostomicin B1, respectively. Fidaxomicin is a narrow spectrum antibiotic with excellent activity against Gram-positive bacteria, notably Clostridium difficile. Fidaxomicin acts in the gastrointestinal tract without undue disruption to gut microflora.
Fidaxomicin is used to treat diarrhea caused by Clostridium difficile.
Isolated from Dactylosporangium aurantiacum.
Additional reading: Fidaxomicin Applications
References
• Antibiotic fidaxomicin is an RdRp inhibitor as a potential new therapeutic agent against Zika virus
• Synthesis and Biological Evaluation of Iodinated Fidaxomicin Antibiotics
• First-line Fidaxomicin Use in High-risk Inpatients Reduces Recurrence Rates
• Fidaxomicin for the treatment of Clostridioides difficile in children
• Inhibitory effect of fidaxomicin on biofilm formation in Clostridioides difficile
Not for human therapeutic use or for medicinal purposes. For research applications only.
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Handling | Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Thermal decomposition can lead to release of toxic/corrosive gases and vapors. |