FK506 (Tacrolimus)

  • CAS:104987-11-3
  • Formula:C44H69NO12
  • MW:804.0 Da
  • Appearance:White powder
  • Purity:≥99%
Product Name Qty
FK506 (Tacrolimus)
1 mg
FK506 (Tacrolimus)
5 mg
FK506 (Tacrolimus)
10 mg
FK506 (Tacrolimus)
25 mg


Tacrolimus (FK-506 or Fujimycin) is used in an immunosuppressive agent for allogeneic organ transplant to reduce the activity of the patient’s immune system and lower the risk of organ rejection. It is also used in a topical preparation in the treatment of atopic dermatitis (eczema), severe refractory uveitis after bone marrow transplants, and for the skin condition vitiligo.

FK-506 is a macrolide compound isolated from the bacterium Streptomyces tsukubaensis. It tightly binds to FK506 binding protein (FKBP12). The complex reduces peptidyl-prolyl isomerase activity and inhibits calcineurin by downregulating Ca2+ concentration in T-cells. Nuclear factor of activated T-cells (NFAT) then is not able to move into the nucleus of the T-cell and is unable to increase activity of genes coding for IL-2 and related cytokines.

It is reported that FK-506 has been shown to have an impact on cancer signaling pathways such as MAPK and the p53 pathway. NFAT inhibition via FK506 is shown to affect cancer cell growth, apoptosis, migration, and invasion in prostate cancer.



• Immunosuppressive agent

• Calcineurin inhibitor

• T cell proliferation blocker



• “Long-term safety and efficacy of tacrolimus ointment for the treatment of atopic dermatitis in children”

• “The carcinogenic potential of tacrolimus ointment beyond immune suppression: a hypothesis creating case report”

• “Cyclosporine A and tacrolimus inhibit bladder cancer growth through down-regulation of NFATc1”


Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Prograf; Protopic; Fujimycin; Tsukubaenolide; Modigraf; Advagraf; Protopy; Astagraf XL
Chemical Name
Chemical Formula
Molecular Weight
804.0 Da
White powder
Clear and colorless at 10 mg/mL DMSO or Ethanol
Melting Point
Storage Temp
Tacrolimus, also known as fujimycin or FK506, is an immunosuppressive drug used mainly after allogeneic organ transplant to lower the risk of organ rejection. It achieves this by inhibiting the production of interleukin-2, a molecule that promotes the development and proliferation of T cells, which are vital to the body's learned (or adaptive) immune response. Tacrolimus is also used in the treatment of other T cell-mediated diseases such as eczema and psoriasis. (for which it is applied to the skin in a medicated ointment), severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, Kimura's disease, and the skin condition vitiligo.
Merck Index
Avoid contact with skin, eyes, and personal clothing. Wash hands thoroughly after handling. Avoid breathing fumes. Use only with adequate ventilation. Wear suitable protective clothing, gloves, and eye/face protection. Keep away from sources of ignition. Minimize dust generation and accumulation. Keep container tightly closed. Open and handle container with care. Do not eat, drink, or smoke while handling.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
HandlingAvoid contact with skin, eyes, and personal clothing. Wash hands thoroughly after handling. Avoid breathing fumes. Use only with adequate ventilation. Wear suitable protective clothing, gloves, and eye/face protection. Keep away from sources of ignition. Minimize dust generation and accumulation. Keep container tightly closed. Open and handle container with care. Do not eat, drink, or smoke while handling.
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