Guanidine Thiocyanate

SKU
G-2563
  • CAS:593-84-0
  • Formula:C2H6N4S
  • MW:118.15 Da
  • Appearance:White crystalline powder
  • Purity:≥99%

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Product Name Qty
Guanidine Thiocyanate
5 kg
$900.00
Guanidine Thiocyanate
100 g
$45.00
Guanidine Thiocyanate
500 g
$150.00
Guanidine Thiocyanate
1 kg
$225.00

Description

Guanidine thiocyanate is a compound that is widely used for the isolation and extraction of RNA in biochemical research. In this capacity, it has been used in many studies relating to cell function, signaling and gene expression.

Guanidine thiocyanate can also be used to create whole blood lysates for long-term storage or transportation of samples. Such lysate samples can be stored for a year or more at -20 degrees Celsius. Precipitation of nucleic acid from guanidine thiocyanate lysates using isoproponal has even been shown to allow for sample storage at room temperatures for up to 14 days, as compared to three days for samples that have not undergone the precipitation process.

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
GTC; Guanidinium isothiocyanate; Guanidinium thiocyanate; GuSCN; Aminomethanamidine thiocyanate
SKU
G-2563
CAS #
593-84-0
Chemical Name
guanidine;thiocyanic acid
Chemical Formula
C2H6N4S
Molecular Weight
118.15 Da
Appearance
White crystalline powder
Purity
≥99%
Solubility
Water: 1,420 g/L at 20 °C
Storage Temp
Room temperature
THERAPEUTIC AREA
RNA purification
USE
Guanidine thiocyanate is used for RNA isolation and can solubilize proteins. When the compound is used to solubilize proteins it can be removed by dialysis against urea without difficulty. The hybridization of guanidine thiocyanate-solubilized hepatocytes can be used as a method to quantify mRNA from hepatocytes. Blood sample lysate stored in guanidine thiocyanate has been shown to maintain nucleic acid integrity. Research describes guanidine thiocyanate to be ineffective for RNA isolation of plant tissue with a high levels of secondary metabolites and storage proteins.
Handling
Use in a chemical fume hood, with air supplied by an independent system. Avoid inhalation, contact with eyes, skin and clothing. Avoid the formation of dust and aerosols. Use in a well-ventilated area. Keep away from sources of ignition. Avoid prolonged or repeated exposure.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Use in a chemical fume hood, with air supplied by an independent system. Avoid inhalation, contact with eyes, skin and clothing. Avoid the formation of dust and aerosols. Use in a well-ventilated area. Keep away from sources of ignition. Avoid prolonged or repeated exposure.
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