Herbimycin A, Streptomyces Hygroscopicus

SKU
H-1050
  • CAS:70563-58-5
  • Formula:C30H42N2O9
  • MW:574.7 Da
  • Appearance:Yellow powder
  • Purity:>99% by HPLC

0

1

0

Product Name Qty
Herbimycin A, Streptomyces Hygroscopicus
100 ug
$162.32
Herbimycin A, Streptomyces Hygroscopicus
1 mg
$524.82

Description

Herbimycin A is a benzoquinoid ansamycin antibiotic isolated from a Streptomyces hygroscopicus. Herbimycin A inhibits the 90-kDa heat-shock protein (Hsp90) which provides essential chaperone support to various signal transduction molecules, including certain steroid hormone receptors and select kinases. Herbimycin also inhibits protein tyrosine kinase and angiogenesis.

More Information
Alternate Name/Synonyms
Herbimycin; TAN 420F
SKU
H-1050
CAS #
70563-58-5
Chemical Name
[(4E,6Z,8S,9S,10E,12S,13R,14S,16S,17R)-8,13,14,17-tetramethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate
Chemical Formula
C30H42N2O9
Molecular Weight
574.7 Da
Appearance
Yellow powder
Purity
>99% by HPLC
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Melting Point
N/A
Preparation
N/A
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Herbimycin A is an inhibitor of tyrosine kinase, on protein tyrosine kinase activity and phosphotyrosyl proteins of Ph1-positive leukemia cells
Merck Index
N/A
MDL NUMBER
MFCD00151702
CHEMACX
X1091564-1
INCHI
InChI=1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9-,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1
SMILES
C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=CC=C(C(=O)NC2=CC(=O)C=C([C@@H]1OC)C2=O)/C)OC)OC(=O)N)C)C)OC)OC
Peptide sequence
N/A
RTECS
LX8930000
UN #'S
N/A
PACKING GROUP
N/A
HAZARD CLASS
N/A
Handling
Warning. Neurotoxin. Ensure adequate ventilation, especially in confined areas. Use personal protective equipment as required. Use with local exhaust ventilation. Do not breathe dust/fume/gas/mist/vapors/spray. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
Certificate of Analysis 1
Handling Warning. Neurotoxin. Ensure adequate ventilation, especially in confined areas. Use personal protective equipment as required. Use with local exhaust ventilation. Do not breathe dust/fume/gas/mist/vapors/spray. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
To Top