Herbimycin A, Streptomyces Hygroscopicus

SKU
H-1050
  • CAS:70563-58-5
  • Formula:C30H42N2O9
  • MW:574.7
  • Appearance:Yellow Powder
  • Purity:98%

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1

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Hazardous
Product Name Qty
Herbimycin A, Streptomyces Hygroscopicus
100 ug
$162.32
Herbimycin A, Streptomyces Hygroscopicus
1 mg
$524.82

A benzoquinoid ansamycin antibiotic that acts as a cell permeable inhibitor of tyrosine kinase and inducer of Heat Shock Proteins. Hsp90 inhibitor. Demonstrates anti-angiogenesis activity.

More Information
Alternate Name/Synonyms
Antibiotic TAN 420F
SKU
H-1050
CAS #
70563-58-5
Chemical Name
[(2R,3S,5S,6R,7S,8E,10S,11S,12Z,14E)-2,5,6,11-TETRAMETHOXY-3,7,9,15-TETRAMETHYL-16,20,22-TRIOXO-17-AZABICYCLO[16.3.1]DOCOSA-1(21),8,12,14,18-PENTAEN-10-YL] CARBAMATE
Chemical Formula
C30H42N2O9
Molecular Weight
574.7
Appearance
Yellow Powder
Purity
98%
Solubility
Soluble in Water, Methanol, and DMSO
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Effect of herbimycin A, an inhibitor of tyrosine kinase, on protein tyrosine kinase activity and phosphotyrosyl proteins of Ph1-positive leukemia cells
MDL NUMBER
MFCD00151702
CHEMACX
X1091564-1
INCHI
InChI=1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9-,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1
SMILES
C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=CC=C(C(=O)NC2=CC(=O)C=C([C@@H]1OC)C2=O)/C)OC)OC(=O)N)C)C)OC)OC
Peptide sequence
Not Applicable
GHS Pictograms
0
RTECS
LX8930000
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Warning. Neurotoxin. Ensure adequate ventilation, especially in confined areas. Use personal protective equipment as required. Use with local exhaust ventilation. Do not breathe dust/fume/gas/mist/vapors/spray. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
Certificate of Analysis 1
/media/upload/pdf/H-1050_H-1050,_A7363.pdf
Spec
0
Handling Warning. Neurotoxin. Ensure adequate ventilation, especially in confined areas. Use personal protective equipment as required. Use with local exhaust ventilation. Do not breathe dust/fume/gas/mist/vapors/spray. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
UN #'S Not Applicable
Packing Group Not Applicable
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