747-36-4
433.95
C18H26ClN3O • H2SO4
Water, DMSO
-20°C
Hydroxychloroquine sulfate is an autophagy inhibitor.
A lysosomotropic agent which inhibits autophagy and triggers apoptosis in a variety of cell types. Augments the anticancer activity of DNA-damaging chemotherapy. Antiinflammatory activity. Decreases cell surface expression of TNFα receptors in U937 cells. Has been used to treat alopecia successfully. Clinically useful antimalaria agent. Cell permeable and active in vivo.
Research component for the novel coronavirus (COVID-19). Hydroxychloroquine have been found to be efficient on SARS-CoV-2 and reported to be efficient in Chinese COV-19 patients. It is evaluated that the role of hydroxychloroquine on respiratory viral loads. One study conducted by French, treatment of hydroxychloroquine with azithromycin was even more efficient for COV-19 elimination.
A guideline document by the Italian Society of Infectious and Tropical disease (Lombardy section) recommend the use of hydroxychloroquine 200 mg for 10 days, although the treatment may vary from 5 to 20 days according to clinical severity. The target population ranged from patients with mild respiratory symptoms and comorbidities to patients with severe respiratory failure.
It is available for oral administration in the form of hydroxychloroquine sulfate and has pharmacokinetics similar to chloroquine, with rapid gastrointestinal absorption and renal elimination. It can be used in high doses for long periods with very good tolerance.
Applications:
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
