Hydroxychloroquine sulfate

SKU
H-2451
  • CAS:747-36-4
  • Formula:C18H26ClN3O ∙ H2SO4
  • MW:434.0 Da
  • Appearance:White powder
  • Purity:>98% by TLC

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Product Name Qty
Hydroxychloroquine sulfate
50 mg
$55.00
Hydroxychloroquine sulfate
250 mg
$175.00

Description

Hydroxychloroquine sulfate is an autophagy inhibitor.

A lysosomotropic agent which inhibits autophagy and triggers apoptosis in a variety of cell types1,2. Augments the anticancer activity of DNA-damaging chemotherapy3. Antiinflammatory activity. Decreases cell surface expression of TNFα receptors in U937 cells4. Has been used to treat alopecia successfully5. Clinically useful antimalaria agent. Cell permeable and active in vivo.

Research component for the novel coronavirus (COVID-19). Hydroxychloroquine have been found to be efficient on SARS-CoV-2 and reported to be efficient in Chinese COV-19 patients. It is evaluated that the role of hydroxychloroquine on respiratory viral loads. One study conducted by French, treatment of hydroxychloroquine with azithromycin was even more efficient for COV-19 elimination6.

A guideline document by the Italian Society of Infectious and Tropical disease (Lombardy section) recommend the use of hydroxychloroquine 200 mg for 10 days, although the treatment may vary from 5 to 20 days according to clinical severity. The target population ranged from patients with mild respiratory symptoms and comorbidities to patients with severe respiratory failure7.

It is available for oral administration in the form of hydroxychloroquine sulfate and has pharmacokinetics similar to chloroquine, with rapid gastrointestinal absorption and renal elimination. It can be used in high doses for long periods with very good tolerance8.

 

Applications:

• Study of SARS-COV-2, COVID-19 and malaria 
 

References:

1. P Boya et al. Mol. Cell Biol. 2005 25:1025

2. X Xie et al. PLoS One 2013 8:e55096

3. Y Pan et al. Clin. Cancer Res. 2011 150:3248

4. JY Jeong et al. Immunology 2002 105:83

5. F Stephan et al. J. Am. Acad. Dermatol. 2013 68:1048

6. “Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial” 

7.“A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19”

8. “New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?”

  

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Hydroxychloroquine; Hydroxychloroquine sulphate; Ercoquin; Plaquinol; Toremonil; Oxichlorochine sulfate
SKU
H-2451
CAS #
747-36-4
Chemical Name
7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline, sulfate
Chemical Formula
C18H26ClN3O ∙ H2SO4
Molecular Weight
434.0 Da
Appearance
White powder
Purity
>98% by TLC
Solubility
May be dissolved in: water (40 mg/mL); DMSO (nil)
Storage Temp
Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20°C for up to 3 months.
THERAPEUTIC AREA
Infectious Diseases
USE
Lupus erythematosus suppressant as well as an antimalerial and antirheumatic. Research being conducted for use as treatment for novel coronavirus (COVID19).
MDL NUMBER
MFCD00078203
CHEMACX
X1004372-8
INCHI
InChI=1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
SMILES
CCN(CCCC(C)Nc1ccnc2c1ccc(c2)Cl)CCO.OS(=O)(=O)O
RTECS
KK3342500
Handling
Thermal decomposition can lead to release of toxic/corrosive gases and vapors.
Hazard Image
Yes
Certificate of Analysis 1
Handling Thermal decomposition can lead to release of toxic/corrosive gases and vapors.
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