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Kanamycin Sulfate

SKU
K-1022
  • CAS:25389-94-0
  • Formula:C18H36N4O11•H2SO4
  • MW:582.58 Da
  • Appearance:White to off-white crystalline powder
  • Purity:>95%

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SDS
CofA
Product Name Qty
Kanamycin Sulfate
10 g
$67.82
Kanamycin Sulfate
25 g
$114.31
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Description

Kanamycin is an aminoglycosidic antibiotic that inhibits growth of gram-positive, gram-negative bacteria and mycoplasmas in cell culture. Kanamycin or kanamycin A is a major component of the antibiotic complex produced by certain strains of Streptomyces kanamyceticus. Kanamycin is supplied in two forms, a crystalline monosulfate monohydrate and a salt with a higher sulfate content. Kanamycin sulfate, which is sometimes referred to as “kanamycin bisulfate,” is obtained by adding sulfuric acid to a solution of the monosulfate and drying using a suitable procedure. Kanamycin sulfate binds to 30S ribosomes causing inhibition of bacterial protein synthesis.

Applications

Laboratory Use - resistance marker to grow plasmids of interest in competent bacterial cells.

Therapeutic Use - a second-line anti-tuberculosis drug.

Specifications

EC Number: 246-933-9

 

More Information
Alternate Name/Synonyms
Kanamycin; Kanamycin A; Kanamycin Sulfate Salt; Kanamycin monosulfate; Kanamycin acid sulfate; Kantrex, Ophtalmokalixan
SKU
K-1022
CAS #
25389-94-0
Chemical Name
(2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acid
Chemical Formula
C18H36N4O11•H2SO4
Molecular Weight
582.58 Da
Appearance
White to off-white crystalline powder
Purity
>95%
Solubility
Soluble in water
Melting Point
250° C
Storage Temp
Room temperature
THERAPEUTIC AREA
Bacterial infections
USE
Kanamycin A Monosulfate is an antibiotic that belongs to the family of aminoglycosides. The antibiotic associates with ribosomal RNA by forming a complex at the bacterial ribosomal A site. Studies show that when Kanamycin A and Neomycin B (sc-338359) are conjugated through lipid conjugation there is an increase of antibacterial activity against methicillin-resistant Staphylococcus epidermidis (MRSE) from Kanamycin A and methicillin-resistant Staphylococcus aureus (MRSA) from both antibiotics.
Merck Index
13.5299.2001
MDL NUMBER
MFCD00070253
CHEMACX
X1004299-4
PubChecm ID
441374
INCHI
InChI=1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1
SMILES
C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)N)O)N.OS(=O)(=O)O
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Handle in accordance with good industrial hygiene and safety practice. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
msds 1
K-1022, Kanamycin sulfate, SDS, diamond format, r01, 2020.pdf
Certificate of Analysis 1
K-1022, K1189A r01.pdf
Certificate of Analysis 2
K-1022, H1116A.pdf
Certificate of Analysis 3
K-1022, H1116.pdf
GHS PICTOGRAMS
Handling Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Handle in accordance with good industrial hygiene and safety practice. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
Citations El papel del Glutatión en la respuesta a estrés oxidante del hongo patógeno oportunista Candida glabrata.
El papel del Glutatión en la respuesta a estrés oxidante del hongo patógeno oportunista Candida glabrata
CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium
An active β-lactamase is a part of an orchestrated cell wall stress resistance network of Bacillus subtilis and related rhizosphere species
Collective Vortex-Like Movement of Bacillus subtilis Facilitates the Generation of Floating Biofilms
Disturbance of the bacterial cell wall specifically interferes with biofilm formation
Mechanisms of tolerance to Melaleuca alternifoli(tea tree) oil in Pseudomonas aeruginosa
Mechanisms of tolerance to Melaleuca alternifolia (tea tree) oil in Pseudomonas aeruginosa
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