Lovastatin

Product Name	Qty
Lovastatin 50 mg $117.30
Lovastatin 10 mg $66.29
Lovastatin 100 mg $203.99

Description

Lovastatin (also known as mevinolin or MK-803) is a cell-permeable inhibitor of hydroxymethylglutaryl coenzyme A reductase (HMG-CoA reductase) derived from Aspergillus terreus. By inhibiting HMG-CoA reductase, lovastatin impedes biosynthesis of mevalonic acid. This effect, in turn, reduces the synthesis of cholesterol in the human body.

Applications

Lovastatin is used in clinical medicine as a treatment for high cholesterol levels in the bloodstream. It can also be used to reduce the risk of atherosclerosis or to slow the progression of the condition in patients who have already developed it. Recent research into lovastatin and statin drugs in general has focused heavily on the adverse effects of these drugs on skeletal muscle and tendon tissues.

Specifications

More Information

Alternate Name/Synonyms

mevinolin; Mevacor; Lovalip; Monacolin K; Altoprev; Lovalord; Mevinacor; Nergadan; Altocor; Artein

SKU

L-1043

CAS #

75330-75-5

Chemical Name

[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate

Chemical Formula

C₂₄H₃₆O₅

Molecular Weight

404.55 Da

Appearance

White powder

Purity

≥98% (HPLC)

Solubility

Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

Melting Point

175.4 °C

Preparation

N/A

Storage Temp

-20°C

THERAPEUTIC AREA

Cardiological disorders, Metabolic disorders

USE

Lovastatin inhibits HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase), blocking the enzyme-catalyzed transformation of 3-hydroxy-3-methylglutaryl CoA into mevalonate. The biosynthesis of cholesterol requires mevalonate as a building block and elimination of mevalonate generation subsequently interrupts cholesterol synthesis, leading to a reduction of circulating low-density lipoproteins. Lovastatin demonstrates arrest of the cell cycle at the G1 phase in bladder carcinoma T24 cells expressing activated p21ras oncoprotein - the posttranslational isoprenylation of the p21ras with mevalonate is crucial for translocation and membrane adhesion of the protein, and blockade of this modification by Lovastatin-induced depletion of cellular mevalonate leads to suspension of cell progress. The signaling activity of epidermal growth factor (EGF) and insulin-like growth factor (IGF-I) are similarly affected by impairment of mevalonate-dependent protein prenylation. Induction of apoptosis by Lovastatin in malignant mesothelioma cells is also ascribed to the inhibition of mevalonate synthesis and posttranslational protein modifications.

Merck Index

13.5608.2001

MDL NUMBER

MFCD00072164

CHEMACX

X1000555-1

INCHI

PCZOHLXUXFIOCF-BXMDZJJMSA-N

SMILES

CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C

Peptide sequence

Not Applicable

RTECS

EK7907000

UN #'S

Not Applicable

PACKING GROUP

Not Applicable

HAZARD CLASS

Not Applicable

Handling

Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation

Certificate of Analysis 1

L-1043, H1179C.pdf

Certificate of Analysis 2

L-1043, H1179B.pdf

Certificate of Analysis 3

L-1043, H1179A.pdf

Reviews

Safety

GHS PICTOGRAMS
Handling	Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation
UN #'S	Not Applicable
Packing Group	Not Applicable

Citations

Citations	Crosstalk between cytosolic and plastidial pathways of isoprenoid biosynthesis in Arabidopsis thaliana
	A combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65
	Consumption of oxygen: a mitochondrial-generated progression signal of advanced cancer
	Statin compounds reduce human immunodeficiency virus type 1 replication by preventing the interaction between virion-associated host intercellular adhesion molecule 1 and its natural cell surface ligand LFA-1
	Dietary Monascus adlay supplements facilitate suppression of cigarette smoke-induced pulmonary endoplasmic reticulum stress, autophagy, apoptosis and emphysema-related PLGF in the rat
	Lovastatin inhibits oxidized L-A-phosphatidylcholine B-arachidonoyl-gamma-palmitoyl (ox-PAPC)-stimulated interleukin-8 mRNA and protein synthesis in human aortic endothelial cells by depleting stores of geranylgeranyl pyrophosphate
	PAF-receptor antagonists, lovastatin, and the PTK inhibitor genistein inhibit H2O2 secretion by macrophages cultured on oxidized-LDL matrices
	The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3)
	Transcytotic efflux from early endosomes is dependent on cholesterol and glycosphingolipids in polarized hepatic cells
	Herbivore-induced terpenoid emission in Medicago truncatula: concerted action of jasmonate, ethylene and calcium signaling
	The YTA7 gene is involved in the regulation of the isoprenoid pathway in the yeast Saccharomyces cerevisiae
	Dynamics of increased neutrophil adhesion to ICAM-1 after contacting immobilized IL-8
	Specificity of anion binding in the substrate pocket of bacteriorhodopsin
	Reduction of protein synthesis and statin-induced cardiomyocyte cell death
	Lovastatin inhibits phenylephrine-induced ERK activation and growth of cardiac
	Lovastatin Inhibits Phenylephrine-Induced ERK Activation and Growth of Cardiac Myocytes
	Determination of lovastatin hydroxy acid in female B6C3F1 mouse serum
	The association between RhoB and caspase-2: changes with lovastatin-induced apoptosis
	Cytoskeletal actin degradation induced by lovastatin in cardiomyocytes is mediated through caspase-2
	Lovastatin Induces Cell Death in Cardiomyocytes that Is Not Reversible by Coenzyme Q 10
	The Role of ERK1/2 in the Progression of Anti-Androgen Resistance of MtDNA Deficient Prostate Cancer
	A predictive model for transcriptional control of physiology in a free living cell
	A transcription network of interlocking positive feedback loops maintains intracellular iron balance in archaea
	Two transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon
	General transcription factor specified global gene regulation in archaea
	Sense overlapping transcripts in IS1341-type transposase genes are functional non-coding RNAs in archaea
	Development of New Modular Genetic Tools for Engineering the Halophilic Archaeon Halobacterium salinarum
	Monascus Adlay and Monacolin K Attenuates Arterial Thrombosis in Rats through the Inhibition of ICAM-1 and Oxidative Stress
	Anticancer effects of Chinese red yeast rice versus monacolin K alone on colon cancer cells
	Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity

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