mevinolin; Mevacor; Lovalip; Monacolin K; Altoprev; Lovalord; Mevinacor; Nergadan; Altocor; Artein

L-1043

75330-75-5

[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate

C₂₄H₃₆O₅

404.55 Da

White powder

≥98% (HPLC)

Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

175.4 °C

N/A

-20°C

Cardiological disorders, Metabolic disorders

Lovastatin inhibits HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase), blocking the enzyme-catalyzed transformation of 3-hydroxy-3-methylglutaryl CoA into mevalonate. The biosynthesis of cholesterol requires mevalonate as a building block and elimination of mevalonate generation subsequently interrupts cholesterol synthesis, leading to a reduction of circulating low-density lipoproteins. Lovastatin demonstrates arrest of the cell cycle at the G1 phase in bladder carcinoma T24 cells expressing activated p21ras oncoprotein - the posttranslational isoprenylation of the p21ras with mevalonate is crucial for translocation and membrane adhesion of the protein, and blockade of this modification by Lovastatin-induced depletion of cellular mevalonate leads to suspension of cell progress. The signaling activity of epidermal growth factor (EGF) and insulin-like growth factor (IGF-I) are similarly affected by impairment of mevalonate-dependent protein prenylation. Induction of apoptosis by Lovastatin in malignant mesothelioma cells is also ascribed to the inhibition of mevalonate synthesis and posttranslational protein modifications.

13.5608.2001

MFCD00072164

X1000555-1

PCZOHLXUXFIOCF-BXMDZJJMSA-N

CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C

Not Applicable

9,4

EK7907000

Not Applicable

Not Applicable

Not Applicable

Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation

/media/upload/pdf/L-1043, H1179C.pdf

/media/upload/pdf/L-1043, H1179B.pdf

/media/upload/pdf/L-1043, H1179A.pdf