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Neomycin C Sulfate

SKU
N-1055
  • CAS:66-86-4
  • Formula:C23H46N6O13• H2SO4
  • MW:614.64 (Free base)
  • Appearance:White powder
  • Purity:98.25%

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CofA
Product Name Qty
Neomycin C Sulfate
10 mg
$363.80
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Description

Neomycin C is a tetracyclic aminoglycoside antibiotic derived from Streptomyces fradiae. Along with Neomycin B, Neomycin C is one of the active components of the broader Neomycin complex. Studies comparing the efficacy of the two against Staphylococcus epidermidis suggest that Neomycin C is approximately 50 percent as biologically active as Neomycin B. This antibiotic binds to the 30S ribosomal subunit within bacterial cells, thus causing DNA to be misread and ultimately leading to cell death. Neomycin C is particularly active against Gram-positive bacteria.

Applications

In laboratory use, Neomycin C is often used as a selection marker to isolate bacteria which have developed resistance to the Neomycin complex. In its sulfate form, Neomycin may also be administered clinically as a means to suppress intestinal bacteria prior to surgical operations. Under some circumstances, Neomycin may be administered as a topical antibiotic, though high rates of contact sensitivity have been reported in conjunction with this application.

• Neomycin is also used in milk replacers in combination with oxytetracycline to control and prevent diseases in cattle.
• In vitro studies have indicated that neomycin C is 50% as active as neomycin B against Staphylococcus epidermidis.

 

More Information
Alternate Name/Synonyms
Neomycin C; Neomycin C Hexaacetate; Dekamycin II Hexaacetate; O-2,6-Diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→3)-O-β-D-ribofuran osyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-streptamine Hexaacetate
SKU
N-1055
CAS #
66-86-4
Chemical Name
(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol
Chemical Formula
C23H46N6O13• H2SO4
Molecular Weight
614.64 (Free base)
Appearance
White powder
Purity
98.25%
Storage Temp
-20°C
THERAPEUTIC AREA
Antibacterial
USE
Neomycin C Sulfate is used as a selection agent for prokaryotic cells transformed with the neo gene or NPT II resistance gene and to study toxic antibacterial side effects. It can be used in a variety of cell culture application, antimicrobial susceptibility testing and food testing in TSN agar to select for Clostridium perfringens.
Handling
Wear appropriate protective clothing/gear to prevent contact with skin and eyes. Provide exhaust ventilation or respiratory protection in areas where dust is formed.
Certificate of Analysis 1
N-1055, J1185.pdf
Certificate of Analysis 2
N-1055, G1231A.pdf
Certificate of Analysis 3
N-1055, G1231.pdf
GHS PICTOGRAMS
Handling Wear appropriate protective clothing/gear to prevent contact with skin and eyes. Provide exhaust ventilation or respiratory protection in areas where dust is formed.
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