Neomycin Sulfate, USP

SKU
N-1053
  • CAS:1405-10-3
  • Formula:C23H46N6O13 • 3H2SO4
  • MW:908.9 Da
  • Appearance:White to yellowish powder

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Product Name Qty
Neomycin Sulfate, USP
500 g
$404.99
Neomycin Sulfate, USP
1 kg
$599.99
Neomycin Sulfate, USP
25 g
$49.99
Neomycin Sulfate, USP
100 g
$124.99

Description

Neomycin sulfate is an aminoglycoside antibiotic that is derived from Streptomyces fradiae. Like other aminoglycosides, neomycin sulfate acts by binding itself to the 30S ribosomal subunit inside the cells of pathogenic bacteria. As a result of this binding, the bacteria misread the subunit and nonfunctional proteins are synthesized, eventually killing the bacterial cells.

Applications

Neomycin sulfate is used clinically as a preventative measure against infections during intestinal surgeries. Neomycin may also be administered in cases of hepatic coma to target urease-producing bacteria in the gastrointestinal system. Suppression of these bacteria limits the production of available ammonia, in turn lowering serum and CSF levels.

This aminoglycoside has also been shown to affect insulin signaling in the human body. Specifically, neomycin sulfate can prevent wortmannin inhibition of the glucose transporter Glut4. This effect is a result of neomycin's ability to mask the substrate of PI3K.

 

More Information
Alternate Name/Synonyms
Framycetin sulphate; Neomycin Trisulfate Hydrate; Neomycin B sulfate
SKU
N-1053
CAS #
1405-10-3
Chemical Name
(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol;sulfuric acid
Chemical Formula
C23H46N6O13 • 3H2SO4
Molecular Weight
908.9 Da
Appearance
White to yellowish powder
Purity
N/A
Solubility
Soluble in water.
Melting Point
N/A
Preparation
N/A
Storage Temp
20°C, desiccated
THERAPEUTIC AREA
Bacterial infections
USE
Neomycin Sulfate is an aminoglycoside antibiotic and calcium channel protein inhibitor which inhibits PLC (Phospholipase C) via binding to inositol phospholipids. It is used as a selection agent for prokaryotic cells that have been transformed using the selectable marker gene (neo), and to study ototoxic side effects of antibiotics, platelet-derived growth factor responses in certain fibroblasts, and extraction of Nuclear Phosphatidylinositol 4,5-Bisphosphate-Interacting Proteins.
Merck Index
13.6482.2001
RTECS
QP4375000
Handling
Use only under a chemical fume hood. Wear personal protective equipment. Avoid dust formation. Do not get in eyes, on skin, or on clothing. Do not breathe vapors/dust. Do not ingest.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Use only under a chemical fume hood. Wear personal protective equipment. Avoid dust formation. Do not get in eyes, on skin, or on clothing. Do not breathe vapors/dust. Do not ingest.
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