Okadaic Acid, Potassium Salt

SKU

O-1028

CAS:155751-72-7
Formula:C₄₄H₆₇O₁₃•K
MW:843.09 Da
Appearance:White crystalline solid or clear, colorless film
Purity:>98%

SDS

CofA

Product Name	Qty
Okadaic acid.Potassium Salt, Prorocentrum concavum 50 ug $127.50
Okadaic acid.Potassium Salt, Prorocentrum concavum 100 ug $204.00
Okadaic acid.Potassium Salt, Prorocentrum concavum 1 mg $1,122.00

Details

Description

Okadaic acid is an inhibitor of PP-1 and PP-2A phosphatase proteins which occurs naturally as a neurotoxin. By inhibiting these proteins, okadaic acid causes an increase in myosin phosphorylation, inducing contraction of affected smooth muscle tissues. The acid was initially discovered in marine sponges of the genus Halichondria but can also be found in toxic shellfish. Our Okadaic acid is isolated from Prorocentrum concavum.

Applications

Owing to its ability to inhibit them, okadaic acid is used to identify phosphatases. In experiments examining the role of phosphorylation in pathological conditions, okadaic acid is used as a chemical probe for the process that can easily permeate cells. The acid has also been shown to promote both the growth of tumors and angiogenesis.

Specifications

More Information

Alternate Name/Synonyms

MFCD00214356; Okadaic Acid, Potassium Salt; 9,10-Deepithio-9,10-didehydroacanthifolicin; Halochondrine A

SKU

O-1028

CAS #

155751-72-7

Chemical Name

potassium;2-hydroxy-3-[11-hydroxy-2-[4-[4-hydroxy-2-[1-hydroxy-3-(3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl)butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5'-oxolane]-2'-yl]but-3-en-2-yl]-4-methyl-1,7-dioxaspiro[5.5]undec-4-en-8-yl]

Chemical Formula

C₄₄H₆₇O₁₃•K

Molecular Weight

843.09 Da

Appearance

White crystalline solid or clear, colorless film

Purity

>98%

Solubility

Soluble in DMSO or ethanol.

Melting Point

164-166°C

Storage Temp

Store desiccated at -20°C. Packaged under argon gas.

THERAPEUTIC AREA

Not Available

USE

Okadaic Acid, Potassium Salt is a potent inhibitor of serine/threonine-specific protein phosphatases PP1, PP2A, 5534, PP2C and endogenous phosphatase smooth muscle myosin. This inhibition action has been used to stimulate the activity of glucose transport and has been observed to block insulin's stimulation of glucose transport by inhibiting IRS-1 phosphorylation. Okadaic Acid, Potassium Salt has been used as a response modifier in the study of large granular lymphocyte and T-cell biochemistry. In addition to inhibitive activities it is a tumor promoter and has been used to study nitric oxide metabolism, apoptosis, cell cycle and calcium signaling.

Merck Index

13.6891.2001

MDL NUMBER

MFCD00213389

CHEMACX

X1094109-2

INCHI

InChI=1S/C44H68O13.K/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42;/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,6H3,(H,48,49);/q;+1/p-1/b10-9+;/t26-,27-,28+,30+,31+,32+,33-,34+,35-,36-,37+,38+,39-,41-,42+,43-,44-;/m1./s1

SMILES

C[C@@H]1CC[C@]2(CCCCO2)O[C@@H]1[C@@H](C)C[C@@H]([C@@H]3C(=C)[C@H]([C@H]4[C@H](O3)CC[C@]5(O4)CC[C@@H](O5)/C=C/[C@@H](C)[C@@H]6CC(=C[C@@]7(O6)[C@@H](CC[C@H](O7)C[C@](C)(C(=O)[O-])O)O)C)O)O.[K+]

RTECS

Not Applicable

UN #'S

UN 2811

PACKING GROUP

HAZARD CLASS

Not Applicable

Handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols.Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs. Provide appropriate exhaust ventilation at places where dust is formed.

Certificate of Analysis 1

O-1028, L1128.pdf

Certificate of Analysis 2

O-1028, H1122G r01.pdf

Certificate of Analysis 3

O-1028, H1122D.pdf

Reviews

Safety

GHS PICTOGRAMS
Handling	Avoid contact with skin and eyes. Avoid formation of dust and aerosols.Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs. Provide appropriate exhaust ventilation at places where dust is formed.
UN #'S	UN 2811
Packing Group	II