Oligomycin

SKU
O-1060
  • CAS:1404-19-9
  • Formula:C45H74O11
  • MW:791.1 Da
  • Appearance:White powder
  • Purity:≥95%

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Product Name Qty
Oligomycin
10 mg
$153.79

Description

Oligomycin Complex of Oligomycin A, B and C. This antibiotic inhibits membrane bound mitochondrial ATPase. It is isolated from Streptomyces diastatochromogenes. Inhibits mitochondrial F1F0 ATP synthase.

A useful tool for decreasing cellular ATP levels. Induces autophagy. Stimulates lysosome acidification. Protects against ischemic kidney in male rats.


Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
SKU
O-1060
CAS #
1404-19-9
Chemical Name
(4E,5'R,6S,6'R,7R,8R,11S,12R,14S,15R,16S,18E,20Z,22R,25S,27S,28R)-22-ethyl-7,11,14,15-tetrahydroxy-6'-(2-hydroxypropyl)-5',6,8,10,12,14,16,28,29-nonamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-oxane]-3,9,13-trione
Chemical Formula
C45H74O11
Molecular Weight
791.1 Da
Appearance
White powder
Purity
≥95%
Solubility
May be dissolved in DMSO (300 mg/mL); or ethanol (200 mg/mL)
Storage Temp
-20°C, desiccated
THERAPEUTIC AREA
Infectious Diseases
USE
Oligomycins are macrolides created by Streptomyces use as antibiotics.
Merck Index
13.6902.2001
MDL NUMBER
MFCD01779388
CHEMACX
X4634181-1
INCHI
InChI=1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13-,17-15-,21-18-
SMILES
CCC1CCC2C(C(C(C3(O2)CCC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)(C)O)C)O)C)C)O)C)C
UN #'S
UN 2811
PACKING GROUP
III
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product.
Citations
Inhibition of Efflux Transporter-Mediated Funqicide Resistance in Pyrenophora triticirepentis by a Derivative of 4'-Hydroxyflavone and Enhancement of Fungicide Activity, Sven Reimann and Holger B.Deising, Appl.Envir. Microbiol., Jun 2005; 71: 3269-3275.
Citations_Hyperlink
http://aem.asm.org/cgi/reprint/71/6/3269
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product.
UN #'S UN 2811
Packing Group III
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