Oligomycin

SKU
O-1060
  • CAS:1404-19-9
  • Formula:C45H74O11
  • MW:791.1 Da
  • Appearance:White powder
  • Purity:≥95%
Product Name Qty
Oligomycin
10 mg
$157.32

Description

Oligomycin Complex of Oligomycin A, B and C. This antibiotic inhibits membrane bound mitochondrial ATPase. It is isolated from Streptomyces diastatochromogenes. Inhibits mitochondrial F1F0 ATP synthase.

A useful tool for decreasing cellular ATP levels. Induces autophagy. Stimulates lysosome acidification. Protects against ischemic kidney in male rats.

 

Additional Reading: Pathology Research Using Mitophagy Modulators

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
SKU
O-1060
CAS #
1404-19-9
Chemical Name
(4E,5'R,6S,6'R,7R,8R,11S,12R,14S,15R,16S,18E,20Z,22R,25S,27S,28R)-22-ethyl-7,11,14,15-tetrahydroxy-6'-(2-hydroxypropyl)-5',6,8,10,12,14,16,28,29-nonamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-oxane]-3,9,13-trione
Chemical Formula
C45H74O11
Molecular Weight
791.1 Da
Appearance
White powder
Purity
≥95%
Solubility
May be dissolved in DMSO (300 mg/mL); or ethanol (200 mg/mL)
Storage Temp
-20°C, desiccated
THERAPEUTIC AREA
Infectious Diseases
USE
Oligomycins are macrolides created by Streptomyces use as antibiotics.
Merck Index
13.6902.2001
MDL NUMBER
MFCD01779388
CHEMACX
X4634181-1
INCHI
InChI=1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13-,17-15-,21-18-
SMILES
CCC1CCC2C(C(C(C3(O2)CCC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)(C)O)C)O)C)C)O)C)C
UN #'S
UN 2811
PACKING GROUP
III
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product.
Citations
Inhibition of Efflux Transporter-Mediated Funqicide Resistance in Pyrenophora triticirepentis by a Derivative of 4'-Hydroxyflavone and Enhancement of Fungicide Activity, Sven Reimann and Holger B.Deising, Appl.Envir. Microbiol., Jun 2005; 71: 3269-3275.
Citations_Hyperlink
http://aem.asm.org/cgi/reprint/71/6/3269
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
HandlingAvoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product.
UN #'SUN 2811
Packing GroupIII
To Top