Polymixin B Sulfate
- MW:1385.61 Da
- Appearance:White to light-yellow powder
- Purity:≥ 80.0 % HPLC
Mixture of sulfates of polypeptides from certain strains of Bacillus polymixa. Active against gram negative bacteria.
Cell culture tested, Potency approximately 6500 units/mg.
The polymyxins are cationic peptides originally isolated from B. polymyxa.1 They bind and kill Gram-negative bacteria.2 The B series of polymyxins consist of a cyclic heptapeptide and a tripeptide side chain acylated at the amino terminus by a fatty acid. Polymyxin B (sulfate) is a mixture of at least four closely related components, polymyxin B1 to B4, with polymyxin B1 (Item No. 14074) and B2 being the two major components.3,4 Polymyxin B (sulfate) has rapid in vitro bactericidal activity against major multidrug-resistant Gram-negative bacteria, such as P. aeruginosa, A. baumannii, and K. pneumoniae.4
EC Number: 215-774-7
|Handling||Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs. Provide appropriate exhaust ventilation at places where dust is formed.|