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Polymixin B Sulfate

SKU
P-2430
  • CAS:1405-20-5
  • Formula:C55H96N16O13•2H2SO4
  • MW:1385.61 Da
  • Appearance:White to light-yellow powder
  • Purity:≥ 80.0 % HPLC

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SDS
CofA
Product Name Qty
Polymixin B Sulfate
1 g
$45.56
Polymixin B Sulfate
5 g
$165.17
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Description

Mixture of sulfates of polypeptides from certain strains of Bacillus polymixa. Active against gram negative bacteria. 

Cell culture tested, Potency approximately 6500 units/mg.

The polymyxins are cationic peptides originally isolated from B. polymyxa.1 They bind and kill Gram-negative bacteria.2 The B series of polymyxins consist of a cyclic heptapeptide and a tripeptide side chain acylated at the amino terminus by a fatty acid. Polymyxin B (sulfate) is a mixture of at least four closely related components, polymyxin B1 to B4, with polymyxin B1 (Item No. 14074) and B2 being the two major components.3,4 Polymyxin B (sulfate) has rapid in vitro bactericidal activity against major multidrug-resistant Gram-negative bacteria, such as P. aeruginosa, A. baumannii, and K. pneumoniae.4 

 

Specifications

EC Number: 215-774-7

 

More Information
Alternate Name/Synonyms
Aerosporin; sufuric acid; Poly-RX
SKU
P-2430
CAS #
1405-20-5
Chemical Name
N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]
Chemical Formula
C55H96N16O13•2H2SO4
Molecular Weight
1385.61 Da
Appearance
White to light-yellow powder
Purity
≥ 80.0 % HPLC
Solubility
Water
Storage Temp
2-8°C
THERAPEUTIC AREA
Infectious Diseases
USE
Polymyxin B is a member of the polymyxin group of antibiotics, obtained from different strains of Bacillus polymyxa and related species. It contains a cyclic heptapeptide unit and a tripeptide side chain, which is N-acylated by a fatty acyl residue. Polymyxin B sulfate salt is generally used for the treatment of Gram-negative bacterial infections. It is used for the treatment of BAC-1.2F5 murine macrophages as an LPS (lipopolysaccharide) inhibitor and as positive and negative control during microbicidal concentration (MCC) assay.
MDL NUMBER
MFCD00131991
PubChecm ID
5702105
INCHI
InChI=1S/C56H98N16O13.H2O4S/c1-7-32(4)13-11-12-16-44(75)63-36(17-23-57)51(80)72-46(34(6)74)56(85)68-39(20-26-60)48(77)67-41-22-28-62-55(84)45(33(5)73)71-52(81)40(21-27-61)65-47(76)37(18-24-58)66-53(82)42(29-31(2)3)69-54(83)43(30-35-14-9-8-10-15-35)70-49(78)38(19-25-59)64-50(41)79;1-5(2,3)4/h8-10,14-15,31-34,36-43,45-46,73-74H,7,11-13,16-30,57-61H2,1-6H3,(H,62,84)(H,63,75)(H,64,79)(H,65,76)(H,66,82)(H,67,77)(H,68,85)(H,69,83)(H,70,78)(H,71,81)(H,72,80);(H2,1,2,3,4)
SMILES
CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O.OS(=O)(=O)O
Handling
Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs. Provide appropriate exhaust ventilation at places where dust is formed.
Certificate of Analysis 1
P-2430, K1535.pdf
Certificate of Analysis 2
P-2430, J1100B.pdf
Certificate of Analysis 3
P-2430, J1100A.pdf
GHS PICTOGRAMS
Handling Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs. Provide appropriate exhaust ventilation at places where dust is formed.
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