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Ponasterone A

SKU
P-1083
  • CAS:13408-56-5
  • Formula:C27H44O6
  • MW:464.6 Da
  • Appearance:Off-white powder
  • Purity:≥96.5%
Product Name Qty
Ponasterone A
5 mg
$198.65
Ponasterone A
1 mg
$52.28
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Description

Ponasterone A is an off-white powder that is part of the ecdysteroid family. It has properties that are similar to muristerone A. It is a steroid hormone in insects that plays a role in regulating metamorphosis. Ponasterone A is a powerful gene expression regulator that rapidly activates and deactivates reporter genes in cells and transgenic organisms.

Ponasterone A is an ecdysone A analog and can function as an economical and reliable substitute for muristerone A. It acts as an ecdysone-inducible mammalian expression system inducer. It is a very bioactive ligand in vivo, displaying continual release and transgene expression.

 

Applications

• Regulation of gene expression
• Can increase cell number at G1 phase while also inhibiting cell growth
• Enables reporter genes to be turned off and on rapidly
• Researchers have used Ponasterone A for studies on iron-related conditions, various cancers in humans, and neurodegenerative diseases

 

More Information
Alternate Name/Synonyms
25-Deoxyecdysterone; 25-Deoxy-20-hydroxyecdysone
SKU
P-1083
CAS #
13408-56-5
Chemical Name
(2S,3R,5R,9R,10R,13R,14S,17S)-17-[(2R,3R)-2,3-dihydroxy-6-methylheptan-2-yl]-2,3,14-trihydroxy-10,13-dimethyl-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one
Chemical Formula
C27H44O6
Molecular Weight
464.6 Da
Appearance
Off-white powder
Purity
≥96.5%
Solubility
Soluble in acetic acid, 100% ethanol, methanol or DMSO.
Storage Temp
-20°C
THERAPEUTIC AREA
Not Available
USE
Ponasterone A is suitable as an inducer of ecdysone-inducible mammalian expression system. It has been used to induce the expression of human huntingtin (HTT). Ecdysteroids such as this compound have been employed as inducers of ecdysone-inducible mammalian expression systems.
Merck Index
14 : 7588
PubChecm ID
115127
INCHI
PJYYBCXMCWDUAZ-JJJZTNILSA-N
SMILES
CC(C)CCC(C(C)(C1CCC2(C1(CCC3C2=CC(=O)C4C3(CC(C(C4)O)O)C)C)O)O)O
Handling
Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
msds 1
P-1083, Ponasterone A, SDS, diamond format.pdf
Certificate of Analysis 1
P-1083, J1038B r02.pdf
Certificate of Analysis 2
P-1083, J1038B.pdf
Certificate of Analysis 3
P-1083, H1239.pdf
HandlingUse only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
CitationsEnterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor
Polyglutamine Tract Expansion Increases S-Nitrosylation of Huntingtin and Ataxin-1
Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid-binding protein YB-1
High-throughput screening of small molecules identifies hepcidin antagonists
Toll-like receptors mediate induction of hepcidin in mice infected with Borrelia burgdorferi
The gene encoding the splicing factor SF2/ASF is a proto-oncogene
Ferroportin-mediated mobilization of ferritin iron precedes ferritin degradation by the proteasome
Direct observation of frequency modulated transcription in single cells using light activation
Basal and Src kinase-mediated activation of the EphA2 promoter requires a cAMP-responsive element but is CREB-independent
Selenoprotein P protects cells from lipid hydroperoxides generated by 15-LOX-1
Discovery of a novel small-molecule targeting selective clearance of mutant huntingtin fragments
Examination of an inducible expression system for limiting iron availability during Chlamydia trachomatis infection
PSAP induces a unique Apaf-1 and Smac-dependent mitochondrial apoptotic pathway independent of Bcl-2 family proteins
Fiberoptic resonance Raman spectroscopy to measure carotenoid oxidative breakdown in live tissues
Upregulation of EphA2 during in vivo and in vitro renal ischemia-reperfusion injury: role of Src kinases
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