Ponasterone A

SKU
P-1083
  • CAS:13408-56-5
  • Formula:C27H44O6
  • MW:464.6 Da
  • Appearance:Off-white powder
  • Purity:≥96.5%

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Product Name Qty
Ponasterone A
5 mg
$194.75
Ponasterone A
1 mg
$51.25

Description

Ponasterone A is an off-white powder that is part of the ecdysteroid family. It has properties that are similar to muristerone A. It is a steroid hormone in insects that plays a role in regulating metamorphosis. Ponasterone A is a powerful gene expression regulator that rapidly activates and deactivates reporter genes in cells and transgenic organisms.

Ponasterone A is an ecdysone A analog and can function as an economical and reliable substitute for muristerone A. It acts as an ecdysone-inducible mammalian expression system inducer. It is a very bioactive ligand in vivo, displaying continual release and transgene expression.

 

Applications

• Regulation of gene expression
• Can increase cell number at G1 phase while also inhibiting cell growth
• Enables reporter genes to be turned off and on rapidly
• Researchers have used Ponasterone A for studies on iron-related conditions, various cancers in humans, and neurodegenerative diseases

 

More Information
Alternate Name/Synonyms
25-Deoxyecdysterone; 25-Deoxy-20-hydroxyecdysone
SKU
P-1083
CAS #
13408-56-5
Chemical Name
(2S,3R,5R,9R,10R,13R,14S,17S)-17-[(2R,3R)-2,3-dihydroxy-6-methylheptan-2-yl]-2,3,14-trihydroxy-10,13-dimethyl-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one
Chemical Formula
C27H44O6
Molecular Weight
464.6 Da
Appearance
Off-white powder
Purity
≥96.5%
Solubility
Soluble in acetic acid, 100% ethanol, methanol or DMSO.
Melting Point
N/A
Preparation
N/A
Storage Temp
-20°C
THERAPEUTIC AREA
Not Available
USE
Ponasterone A is suitable as an inducer of ecdysone-inducible mammalian expression system. It has been used to induce the expression of human huntingtin (HTT). Ecdysteroids such as this compound have been employed as inducers of ecdysone-inducible mammalian expression systems.
Merck Index
14 : 7588
PubChecm ID
115127
INCHI
PJYYBCXMCWDUAZ-JJJZTNILSA-N
SMILES
CC(C)CCC(C(C)(C1CCC2(C1(CCC3C2=CC(=O)C4C3(CC(C(C4)O)O)C)C)O)O)O
RTECS
N/A
Handling
Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
Handling Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
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