- Appearance:Off White Solid
PP2 is a substance used in cancer research as a selective inhibitor for Src-family kinases with 10,000-fold selectivity over ZAP-70 and JAK2.PP2 strongly inhibits the kinases Lck (IC50=4 nM), Fyn (5 nM) and Hck (5 nM), shows weaker inhibition of EGFR (480 nM) and practically no inhibition of ZAP-70 (100M) and JAK2 (50M).A Preformed Signaling Complex Mediates GnRH-Activated ERK Phosphorylation of Paxillin and FAK at Focal Adhesions in LT2 Gonadotrope Cells.VASCULAR BIOLOGY Cooperation between integrin 5 and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity .PKC and cofilin activation affects peripheral actin reorganization and cell-cell contact in cells expressing integrin 5 but not its tailless mutant.Binding of IgG-Opsonized Particles to FcR Is an Active Stage of Phagocytosis That Involves Receptor Clustering and Phosphorylation.
Off White Solid
Soluble in water, methanol, DMSO, DMF with moderate ethanol solubility
PP 2 is an effective and selective inhibitor of c-Src family kinases use in cervical cancer
Store in Tightly Sealed Vial
RESEARCH ARTICLES: PKC and cofilin activation affects peripheral actin reorganization and cell-cell contact in cells expressing integrin 5 but not its tailless mutant Min-A Oh, Eun-Sil Kang, Sin-Ae Lee, Eun-Ok Lee, Yong-Bae Kim, Sung-Hoon Kim, and Jung Weon Lee J. Cell Sci., Aug 2007; 120: 2717 - 2730.
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|Handling||Store in Tightly Sealed Vial|
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