PP2
SKU
P-1103
- CAS:172889-27-9
- Formula:C15H16ClN5
- MW:301.8
- Appearance:Off White Solid
- Purity:98%
SDS
CofA
PP2 is a substance used in cancer research as a selective inhibitor for Src-family kinases with 10,000-fold selectivity over ZAP-70 and JAK2.PP2 strongly inhibits the kinases Lck (IC50=4 nM), Fyn (5 nM) and Hck (5 nM), shows weaker inhibition of EGFR (480 nM) and practically no inhibition of ZAP-70 (100M) and JAK2 (50M).A Preformed Signaling Complex Mediates GnRH-Activated ERK Phosphorylation of Paxillin and FAK at Focal Adhesions in LT2 Gonadotrope Cells.VASCULAR BIOLOGY Cooperation between integrin 5 and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity .PKC and cofilin activation affects peripheral actin reorganization and cell-cell contact in cells expressing integrin 5 but not its tailless mutant.Binding of IgG-Opsonized Particles to FcR Is an Active Stage of Phagocytosis That Involves Receptor Clustering and Phosphorylation.
More Information
Alternate Name/Synonyms
4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4,d]pyrimidine
SKU
P-1103
CAS #
172889-27-9
Chemical Name
1-tert-Butyl-3-(4-chlorophenyl)- 1H-pyrazolo[3,4-d]pyrimidin-4-amine
Chemical Formula
C15H16ClN5
Molecular Weight
301.8
Appearance
Off White Solid
Purity
98%
Solubility
Soluble in water, methanol, DMSO, DMF with moderate ethanol solubility
Melting Point
214-216 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
PP 2 is an effective and selective inhibitor of c-Src family kinases use in cervical cancer
MDL NUMBER
MFCD01568210
CHEMACX
X1486321-1
INCHI
InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)
SMILES
CC(C)(C)n1c2c(c(n1)c3ccc(cc3)Cl)c(ncn2)N
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Store in Tightly Sealed Vial
Citations
RESEARCH ARTICLES:
PKC and cofilin activation affects peripheral actin reorganization and cell-cell contact in cells expressing integrin 5 but not its tailless mutant
Min-A Oh, Eun-Sil Kang, Sin-Ae Lee, Eun-Ok Lee, Yong-Bae Kim, Sung-Hoon Kim, and Jung Weon Lee
J. Cell Sci., Aug 2007; 120: 2717 - 2730.
Citations_Hyperlink
http://jcs.biologists.org/cgi/reprint/120/15/2717
Certificate of Analysis 1
Certificate of Analysis 2
| GHS PICTOGRAMS |
|
|---|---|
| Handling | Store in Tightly Sealed Vial |
| UN #'S | Not Applicable |
| Packing Group | Not Applicable |
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