PP2

SKU
P-1103
  • CAS:172889-27-9
  • Formula:C15H16ClN5
  • MW:301.8
  • Appearance:Off White Solid
  • Purity:98%
Product Name Qty
PP2
1 mg
$93.40
PP2
5 mg
$364.51
PP2 is a substance used in cancer research as a selective inhibitor for Src-family kinases with 10,000-fold selectivity over ZAP-70 and JAK2.PP2 strongly inhibits the kinases Lck (IC50=4 nM), Fyn (5 nM) and Hck (5 nM), shows weaker inhibition of EGFR (480 nM) and practically no inhibition of ZAP-70 (100M) and JAK2 (50M).A Preformed Signaling Complex Mediates GnRH-Activated ERK Phosphorylation of Paxillin and FAK at Focal Adhesions in LT2 Gonadotrope Cells.VASCULAR BIOLOGY Cooperation between integrin 5 and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity .PKC and cofilin activation affects peripheral actin reorganization and cell-cell contact in cells expressing integrin 5 but not its tailless mutant.Binding of IgG-Opsonized Particles to FcR Is an Active Stage of Phagocytosis That Involves Receptor Clustering and Phosphorylation.
More Information
Alternate Name/Synonyms
4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4,d]pyrimidine
SKU
P-1103
CAS #
172889-27-9
Chemical Name
1-tert-Butyl-3-(4-chlorophenyl)- 1H-pyrazolo[3,4-d]pyrimidin-4-amine
Chemical Formula
C15H16ClN5
Molecular Weight
301.8
Appearance
Off White Solid
Purity
98%
Solubility
Soluble in water, methanol, DMSO, DMF with moderate ethanol solubility
Melting Point
214-216 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
PP 2 is an effective and selective inhibitor of c-Src family kinases use in cervical cancer
MDL NUMBER
MFCD01568210
CHEMACX
X1486321-1
INCHI
InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)
SMILES
CC(C)(C)n1c2c(c(n1)c3ccc(cc3)Cl)c(ncn2)N
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Store in Tightly Sealed Vial
Citations
RESEARCH ARTICLES: PKC and cofilin activation affects peripheral actin reorganization and cell-cell contact in cells expressing integrin 5 but not its tailless mutant Min-A Oh, Eun-Sil Kang, Sin-Ae Lee, Eun-Ok Lee, Yong-Bae Kim, Sung-Hoon Kim, and Jung Weon Lee J. Cell Sci., Aug 2007; 120: 2717 - 2730.
Citations_Hyperlink
http://jcs.biologists.org/cgi/reprint/120/15/2717
Certificate of Analysis 1
Certificate of Analysis 2
GHS PICTOGRAMS
Handling Store in Tightly Sealed Vial
UN #'S Not Applicable
Packing Group Not Applicable
Citations Targeting EphA4 abrogates intrinsic resistance to chemotherapy in well-differentiated cervical cancer cell line
Molecular mechanisms underlying the anti-proliferative and anti-migratory effects of folate on homocysteine-challenged rat aortic smooth muscle cells
Binding of IgG-Opsonized Particles to Fc R Is an Active Stage of Phagocytosis That Involves Receptor Clustering and Phosphorylation
Folic acid inhibits endothelial cell migration through inhibiting the RhoA activity mediated by activating the folic acid receptor/cSrc/p190RhoGAP-signaling pathway
Progesterone induces RhoA Inactivation in male rat aortic smooth muscle cells through up-regulation of p27(kip1.)
Progesterone-induced migration inhibition in male rat aortic smooth muscle cells through the cSrc/AKT/ERK 2/p38 pathway-mediated up-regulation of p27
Molecular mechanisms underlying progesterone-enhanced breast cancer cell migration
Folic acid inhibits COLO-205 colon cancer cell proliferation through activating the FRα/c-SRC/ERK1/2/NFκB/TP53 pathway: in vitro and in vivo studies
Extra-nuclear activation of progesterone receptor in regulating arterial smooth muscle cell migration
Cell adhesion-dependent cofilin serine 3 phosphorylation by the integrin-linked kinase.c-Src complex
Progesterone receptor activation of extranuclear signaling pathways in regulating p53 expression in vascular endothelial cells
Lipid raft-dependent endocytosis negatively regulates responsiveness of J774 macrophage-like cells to LPS by down regulating the cell surface expression of LPS receptors
Extra-Nuclear Signaling Pathway Involved in Progesterone-Induced Up-Regulations of p21cip1 and p27kip1 in Male Rat Aortic Smooth Muscle Cells
Chlamydia trachomatis tarp is phosphorylated by src family tyrosine kinases
Specific tyrosine phosphorylation of focal adhesion kinase mediated by Fer tyrosine kinase in suspended hepatocytes
Clathrin and Lipid Raft-dependent Internalization of Porphyromonas
Differential roles of PKC isoforms (PKCs) and Ca2+ in GnRH and phorbol 12-myristate 13-acetate (PMA) stimulation of p38MAPK phosphorylation in immortalized gonadotrope cells
Elucidating the signaling pathways regulating syndromic and nonsyndromic rhabdomyosarcoma
Androgen receptor activation reduces the endothelial cell proliferation through activating the cSrc/AKT/p38/ERK/NFκB-mediated pathway
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