DMF, DMSO, Ethanol
AdipoRon is a novel potent and selective adiponectin (AdipoR1 and AdipoR2) receptor agonist, Kd=1.8 and 3.1 μM respectively. Displayed similar effects to adiponectin in muscle and liver such as activation of PPARα and AMPK signaling pathways. It also reversed insulin resistance and glucose intolerance in mice on a high-fat diet. It ameliorated diabetes in a genetically obese mouse model and prolonged the shortened lifespan of db/db mice on a high-fat diet.
Adiporon attenuates post-ischemic myocardial apoptosis and oxidative stress and improves cardiac function in mouse model of myocardial ischemia/reperfusion injury. Active in vivo.
Research or further manufacturing use only, not for food or drug use.