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Amlexanox, 50 MG

PriceCall for Pricing
  • SKU: A-2431-50MG
  • Pack Size: 50 MG

2-amino-7-(1-methylethyl)5-oxo-5H-[1]benzopyrano[2,3- b]pyridine-3-carboxylic acid; AA 673; CHX 3673; Elics

68302-57-8

298.3

C16H14N2O4

DMF, DMSO

-20°C


Amlexanox improves obesity-related metabolic dysfunction in mouse models. It increases thermogenesis and weight loss, decreases steatosis and improves insulin sensitivity. Clinically useful in treatment of aphthus ulsers.

Amlexanox acts by Inhibiting TANK-binding kinase 1(TBK1) and IKKԑ (IC50=1.2 µM). It induces the complete and reversible non-apoptotic inhibition of cell migration and proliferation, and although amlexanox does not induce either the down-regulation of F-actin levels or the depolymerization of actin filaments, it does induce the tyrosine phosphorylation of cortactin, a Src substrate known to regulate actin bundling.

 

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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