(p-methoxyphenyl)morpholino-phosphinodithioic acid
106740-09-4
377.5
C11H16NO2PS2 • C4H10NO
DMF, DMSO, PBS (pH 7.2)
-20°C
A slow-releasing, water-soluble hydrogen sulfide (H2S) donor. Displays vasodilator and antihypertensive activity in rats in both acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models.
Inhibits LPS-induced release of various proinflammatory mediators (such as IL-1β, IL-6, TNF-α, nitric oxide (NO) and PGE2) in RAW264.7 cells. Increases the synthesis of the anti-inflammatory chemokine IL-10 through NF-κB, ATF-2 and HSP27 dependent pathways in RAW264.7 cells.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.