FTY720; 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol, hydrochloride
162359-56-0
343.9
C19H33NO2 • HCl
DMF, DMSO, Ethanol, Ethanol:PBS (pH 7.2)
-20°C
Fingolimod HCl is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herbIscaria sinclari as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1p) receptors. Down-regulation of S1P receptors on T and B lymphocytes by FTY720 results in defective egress of these cells from spleen, lymph nodes, and Peyer's patch. FTY720 also enhances the activity of the sphingosine transporter Abcb1 and the leukotriene C transporter Abcc1 and inhibits cystolic phospholipase A activity.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
