NSC 326408; Roc-A; Rocaglamide A
84573-16-0
505.6
C29H31NO7
DMSO, Ethanol
-20°C
Rocaglamide is an immunosuppressant and a potent inhibitor of NF-B activation in T cells, with an almost complete inhibition at 200 nM. Suppresses cytokine production (IFN-, TNF, IL-2 and IL-4) and inhibits NF-AT in peripheral blood T cells at concentrations that do not impair NF-B and AP-1 activities. Also induces mitochondria-mediated apoptosis in leukemia cells and sensitizes CD95/CD95L-mediated apoptosis in malignant T-cells by differential regulation of CD95L and c-FLIP expression.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
