5,6,6a,7,12,12bS,12cR,13,14,14aS-decahydro-4bS-hydroxy-2R-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-1-benzopyrano[5’,6’:6,7]indeno[1,2-b]indole-3(4bH)-one
57186-25-1
435.6
C27H33O4
Soluble in DMSO, ethanol, petrol ether
-20°C
Description
Paxilline is a tremorogenic indole diterpene and a potent, selective, and reversible inhibitor of high-conductance Ca2+-activated potassium (BKCa) channels in murine smooth muscle cells by stimulating binding of charybdotoxin (ChTX) to maxi-K channels and blocking the channels.
It is reported that a gain-of-function in BK-channel is related to spontaneous seizures in both animal models and humans. For example: epilepsy and paroxysmal movement disorder. Paxilline can cross the blood-brain barrier and downregulate the abnormal activity of gain-of-function in BK-channel.
Applications
• BK-channel antagonist
• Anticonvulsant reagent
• Neuronal diseases study
References
• “Anticonvulsant effects of the BK‐channel antagonist paxilline”
• “Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism”
Not for human therapeutic use or for medicinal purposes. For research applications only.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
