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Dithiothreitol [DTT], 1 KG

Price$ 1,891.75
You Save$ 6608.25
  • SKU: C-1029-1KG
  • Pack Size: 1 KG
Quantity
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Total price: $ 5,657.25

This item: Dithiothreitol [DTT], 1 KG $ 1,891.75

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DTT; DL-Dithiothreitol; Cleland’s reagent; 1,4-Dithio-DLthreitol;threo-1,4-Dimercapto-2,3-butanediol; 1,4- bis(sulfanyl)butane-2,3-diol

3483-12-3

154.25

C4H10O2S2

Water

2-8°C


Dithiothreitol (DTT), is a small-molecule redox reagent, known as Cleland's reagent, that forms a six-member ring with an internal disulfide bond. It has a redox potential of -0.33 V at pH 7. The reduction of typical disulfide bond proceeds by two sequential thiol-disulfide exchange reactions.
 

DTT is effective in buffers to reduce protein disulfide bonds prior to SDS-PAGE. It can protect protein sulfhydryls and restore enzyme activity lost by oxidation.


Applications:

  • For reducing or "deprotecting" agent for thiolated DNA
  • For reducing disulfide bonds of proteins
  • Used as an oxidizing agent
  • Used as a component of medium for the demembranation and reactivation of spermatozoa
  • Used to prevent intramolecular and intermolecular disulfide bonds from forming between cysteine residues of proteins

Additional Reading from AG Scientific:


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2.2 lbs

6.00 x 7.00 x 7.00



Research or further manufacturing use only, not for food or drug use.
  • Appearance: White Crystalline Powder
  • Solubility (10% solution in H2O): Clear and Colorless
  • Melting Point: 40 - 44 oC
  • IR: Consistent with assigned structure
  • Purity (TLC-Spot): One spot
  • UV Assay A280 (1% solution): < 0.067
  • UV Assay A305 (1% solution): < 0.050
  • UV Assay A283 (0.02 M Solution): < 0.040
  • UV Assay A400 (1 M Neutral Solution): < 0.062
  • UV Assay A405 (1 M Neutral Solution): < 0.062
  • UV Assay OD 700-500 nm (1 M Neutral Solution): ≤ 0.035
  • Solubility (10% in H2O): Clear and colorless
  • Oxidized DTT: < 0.50 %
  • Loss on Drying: < 0.50 %
  • Titration KI​​​​​3: ≥ 99.0 %
  • BSE/TSE Free: BSE/TSE Free
  • Country of Origin: Canada
  • Storage & Handling: Store desiccated at 2-8°C under inert gas

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