Acadesine; AICA-Riboside; NSC 105823
2627-69-2
258.2
C9H14N4O5
DMF, DMSO, Ethanol, PBS (pH 7.2)
-20°C
AICAr (AICA-Riboside) is a cell- permeable activator of AMP-activated protein kinase (AMPK), a metabolic sensor involved in both cellular and whole body energy homeostasis. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle. AICAR is able to activate the molecular circuitry of pluripotency in mESC and to induce the expression of several key regulators of pluripotency in somatic cells.
Applications and Effects of AICAr
• AICAr's phosphorylated metabolite activates AMPK and acts as a regulator of de novo purine synthesis.
• Kinase phosphatase biology research.
• Additional Reading: Pathology Research Using Mitophagy Modulators
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
