5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
347.4
C18H22FN3O3
DMSO (10 mg/mL, warm)
-20°C
A potent and selective FOXO1 inhibitor, IC50s=33 nM and >1 uM for FOXO3a and 4. Oral administration to diabetic db/db mice leads to a reduction of fasting plasma glucose levels. Suppresses autophagy, FSP27 expression and adipocyte differentiation. AS1842856 is a highly useful tool for probing the involvement of FOXO1 in cellular processes.
Store solutions at -20°C for up to 3 months.
Research or further manufacturing use only, not for food or drug use.
