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Torin-1, 25 MG

Price$ 320.00
  • SKU: T-2902-25MG
  • Pack Size: 25 MG
Quantity
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+

1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one

1222998-36-8

607.6

C35H28F3N5O2

DMSO

-20°C


Torin-1 is a potent and selective ATP-competitive mTOR inhibitor, IC50=2 and 10 nM for mTORC1 and mTORC2 respectively. Active in vivo at inhibition of mTOR-mediated effects in mice (20 mg/kg). Induces autophagy. Torin 1-mediated enhancement of TFEB-mediated autophagy alleviates neuronal death in oxidative stress-induced disease models. Downregulates NGF expression in RSC96 cells.

 



Research or further manufacturing use only, not for food or drug use.

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