APO-866; Daporinad; K 22.175
DMF, DMSO, Ethanol
FK-866 is a cell-permeable, highly specific, non-competitive inhibitor of Nicotinamide phosphoribosyltransferase (NAMPT) (K = 0.4 nM), causing gradual NAD+ depletion.
NAMPT functions as an intra-cellular and extra-cellular NAD biosynthetic enzyme that is important for regulating metabolism and stress resistance through sirtuins and other NAD-consuming regulators. NAD+ depletion by FK-866 directs delayed cell death by apoptosis in Hep-G2 human liver carcinoma cells.
Research or further manufacturing use only, not for food or drug use.