Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
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Oligomycin D (rutamycin) is macrocyclic lactone belonging to the oligomycin class but identified from different species of Streptomyces in 1961. Like oligomycin A, oligomycin D inhibits mitochondrial F1F0-ATPase and is an important bioprobe to study the organisation of ATPase on the mitochondrial membrane.
Oligomycin D exhibits a broad biological profile including antifungal, antitumor and nematocidal activities.
Isolated from Streptomyces sp.
• Antifungal antibiotic rutamycin and process for the production thereof. Thompson R.Q. US Patent 3,310,468,
• Assembly of the mitochondrial system. Purification of a mitochondrial product of the ATPase. Sierra M.F. &
Tzagoloff A. Proc. Natl. Acad. Sci. U.S.A. 1973, 70, 3155.
Not for human therapeutic use or for medicinal purposes. For research applications only.
Research or further manufacturing use only, not for food or drug use.