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Leupeptin Hemisulfate, 10 MG

Price$ 58.24
You Save$ 15.88
  • SKU: L-1165-10MG
  • Pack Size: 10 MG
Quantity
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103476-89-7

951.2 Da

C40H78N12O12S

Soluble in water (50 mg/mL), clear and colorless to faint yellow solution

-20°C


Description

Leupeptin is a reversabile protease inhibitor known to target various cathepsins, calpain and trypsin. In biochemical research, leupeptin is used frequently as a reducing agent in experiments designed to study proteins, enzymes, amino acids and neuropeptides.

Applications

While it is used widely as a reagent, several studies have been conducted into leupeptin's direct biomedical effects. In one such study, leupeptin was shown to protect hair cells in the inner ear from ototoxicity associated with aminoglycoside antibiotic treatment. In rat studies, leupeptin has demonstrated a considerable ability to suppress inflammation caused by gingivitis.

Leupeptin has also played a role in studies of certain cancers for several decades. In the early 1970s, the compound was found to have an inhibitory effect on tumorigenesis of skin cancer in mice. More recently, it has been used in studies relating to the role of the protease matriptase in the development of breast cancers.

Leupeptin Solution Protocol

Leupeptin Hemisulfate in methanol stock solution can be prepared at concentration of 20 mg/mL. Store at stock solution at -20°C.

 

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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