Soluble in DMSO; Insoluble in Water.
Paullones represent a novel class of small molecule cyclin-dependent kinase (CDK) inhibitors. Alsterpaullone is a potent inhibitor of CDK/cyclin B (IC=0.035M). High in vitro anti-tumor potency.Cell Cycle-regulated Phosphorylation of Hamartin, the Product of the Tuberous Sclerosis Complex 1 Gene, by Cyclin-dependent Kinase 1/Cyclin B.Formation of the head organizer in hydra involves the canonical Wnt pathway.From the Cover: Wnt/-Catenin and noncanonical Wnt signaling interact in tissue evagination in the simple eumetazoan Hydra.
Research or further manufacturing use only, not for food or drug use.