CGP57148B; STI-571
220127-57-1
589.7
C29H31N7O • CH4SO3
DMF, DMSO, PBS (pH 7.2)
-20°C
Imatinib Mesylate is an inhibitor of the bcr-abl tyrosine kinase. It acts by binding to the ATP binding site of bcr-abl. Imatinib also stimulates the entry of the bcr-abl tyrosine kinase into the nucleus, where it cannot perform its anti-apoptopic functions. It inhibits EOL-1 cell viability (IC= 0.5 nM), phosphorylation of a fusion protein (IC= 30 nM), and viability of BaF3 cells expressing Rhe-PDGFR in the absence of IL-3 (IC= 0.17 nM).
0.1 lbs
Research or further manufacturing use only, not for food or drug use.