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Price$ 52.26
  • SKU: G-2379-1MG
  • Pack Size: 1 MG
Quantity
-
+

1346574-57-9

526.67

C31H38N6O2

Soluble in DMSO

-20°C


GSK-126 is an inhibitor of mutant EZH2, a histone methyltransferase (HMT) that exhibits point mutations at key residues Tyr641 and Ala677; this compound does not appreciably affect WT EZH2. EZH2 is responsible for modulating expression of a variety of genes. GSK-126 competes with cofactor S-adenylmethionine (SAM) for binding to EZH2. GSK-126 displays anticancer chemotherapeutic activity by inhibiting proliferation in in vitro and in vivo models of diffuse large B-cell lymphoma.

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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