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Price$ 60.00
  • SKU: I-1036-200MG
  • Pack Size: 200 MG
Quantity
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28822-58-4

222.3

C10H14N4O2

Soluble in DMSO (15 mg/ml) or ethanol (10 mg/ml)

Room Temperature


Description

IBMX is a potent, non-selective inhibitor of phosphodiesterases (PDE 1,2,3,4,5).

It has been reported that IBMX has an adipogenic effect mediated by suppression of endogenous TNF production. In cultured human preadipocytes and adipocytes, TNF-mRNA expression is suppressed by IBMX.

It is believed that IBMX is related to glucose mechanisms. In diabetic rat models, response of 5’-cyclin monophosphate (cAMP) to glucose and secretion of glucose-induced insulin failed. Addition of IBMX in these models helps them recover their function, accumulating cAMP and releasing insulin responding to glucose.

In neural cells, it has been shown that IBMX transiently elevates the level of Ca2+ from intracellular stores.

 

Applications

• Inhibitor of PDE1, PDE2, PDE3, PDE4, PDE5

• Studies of cAMP

• Studies of Ca2+ in neural cells

 

References

• “Decreased glucose-induced cAMP and insulin release in islets of diabetic rats: reversal by IBMX, glucagon, GIP”

• “IBMX induces calcium release from intracellular stores in rat sensory neurons”

• “The Phosphodiesterase Inhibitor IBMX Suppresses TNF-α Expression in Human Adipocyte Precursor Cells: A Possible Explanation for its Adipogenic Effect”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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