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AEBSF HCl, 10 G

Price$ 740.00
You Save$ 10058.00
  • SKU: A-1018-10GM
  • Pack Size: 10 G
Quantity
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Frequently Bought Together

Total price: $ 3,331.95

This item: AEBSF HCl, 10 G $ 740.00

CHAPS, High Purity, 1 KG $ 2,591.95

30827-99-7

239.5

C8H11ClFNO2S

Clear colorless solution in H2O 50mg/ml

-20°C


Synonym: 4-(2-aminoethyl)benzenesulfonyl fluoride;hydrochloride

Description

AEBSF HCl (also called Pefabloc) is a broad spectrum, water soluble, irreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. It has been shown to inhibit the constitutive production of beta amyloid (A beta) in five different human cell lines, both neural and non-neural.

AEBSF also inhibits activation of TGFβ (transforming growth factor beta), moderately inhibits dipeptidyl peptidase IV (DPP IV) and activates JNK and p38 MAP kinases. AEBSF is a b-secretase inhibitor that has been shown to inhibit beta amyloid peptide production and enhance APP (amyloid precursor protein) secretion in several cell lines at millimolar concentrations.

 

Applications

• TGF beta inhibitor
• JNK activator
• p38 Map activator

 

Specifications

EC Number: 608-547-2

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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