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Price$ 60.50
  • SKU: A-1018-50MG
  • Pack Size: 50 MG

AEBSF hydrochloride; 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride



C8H10FNO2S • HCl



AEBSF HCl is a broad spectrum, water soluble, irreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. It has been shown to inhibit the constitutive production of beta amyloid (A beta) in five different human cell lines, both neural and non-neural.

AEBSF also inhibits activation of TGFβ (transforming growth factor beta), moderately inhibits dipeptidyl peptidase IV (DPP IV) and activates JNK and p38 MAP kinases. AEBSF is a b-secretase inhibitor that has been shown to inhibit beta amyloid peptide production and enhance APP (amyloid precursor protein) secretion in several cell lines at millimolar concentrations.


  • TGF beta inhibitor
  • JNK activator
  • p38 Map activator

0.1 lbs

Research or further manufacturing use only, not for food or drug use.
  • Appearance: White to off-white powder
  • Purity (HPLC, 220NM): ≥ 99 %
  • Identification (1H-NMR): Standard
  • Elemental Analysis as hydrochloride (C): (theory) 40.09 %
  • Elemental Analysis as hydrochloride (H): (theory) 4.63 %
  • Elemental Analysis as hydrochloride (N): (theory) 5.84 %
  • Water Content (K.F): ≤ 1.0 %
  • Melting Point: 181 - 185 oC
  • Solubility: 50 mg/mL in Water Clear Colorless
  • Storage & Handling: Store desiccated at -20°C

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