Quick Order Pad
Your Shopping Cart is Empty
Hello, Sign In

Lactacystin, 100 UG

Price$ 130.75
  • SKU: L-1147-100UG
  • Pack Size: 100 UG

N-Acetyl-S-{[(2R,3S,4R)-3-hydroxy-2-(1-hydroxy-2- methylpropyl)-4-methyl -5-oxo-2-pyrrolidinyl]carbonyl}-Lcysteine




DMSO, Water, Ethanol


Lactacystin is a microbial metabolite of Streptomyces strains and acts as a cell permeable, specific, and irreversible inhibitor of 20S proteasome and lysosomal enzyme, Cathepsin A. It irreversibly binds to N-terminal threonine residue on active site of catalytic B subunit of 20S proteasome and therefore blocks proteolytic activity.

The metabolite blocks the cell cycle and induces neurite outgrowth in a murine neuroblastoma cell line, Neuro-2a. It inhibits cell cycle progression in both the G0/G1 and G2/M phases of the cell cycle. Treatment of Lactacystin in Neuro-2a cells displays bipolar morphology and becomes progressively more multipolar.

Lactacystin induces apoptosis in human monoblastic U937, confirming DNA fragmentation.


0.1 lbs

Research or further manufacturing use only, not for food or drug use.

Product Recommendations