VP-16-123; EPE; NSC 141540
Etoposide is a Topoisomerase II inhibitor derived from podophyllotoxin. It induces apoptosis, autophagy in various cell lines and has a antitumor property so can be used for treatment of cancer. This reagent suppresses DNA synthesis and blocks specific cell cycles because it helps to break double-strand DNA by generating transient double-stranded breaks in the double helix.
Its antitumor property is explained by activation of tumor suppressor p53 and inhibition of synthesis of oncoprotein Mdm2 and overexpress Mdm2 to promote apoptosis.
- Anti-tumor reagent
- Preparation of drug stock solution in dimethyl sulfoxide (DMSO)
- DNA damage inducer
Research or further manufacturing use only, not for food or drug use.