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Topotecan HCl, 10 MG

List Price$ 90.00
Price$ 72.00
You Save$ 18.00
  • SKU: T-2910-10MG
  • Pack Size: 10 MG
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10-[(Dimethylamino)methyl]-4S-ethyl-4,9-dihydroxy-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, HCl; NSC 609669; SKF-104864A

119413-54-6

C23H23N3O5 • HCl

DMSO, Water

-20°C


Water-soluble and orally active analog of camptothecin, a DNA topoisomerase I inhibitor. Inhibits topoisomerase I in human MCF-7 breast and DU-145 prostate cancer cells, IC50s = 13 and 2 nM respectively. Downregulates B-Myb and MycN expression in neuroblastoma cells. A clinically useful anticancer agent.

 



Research or further manufacturing use only, not for food or drug use.

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