Quinomycin A, HIF-1 inhibitor

SKU
Q-1112
  • CAS:512-64-1
  • Formula:C51H64N12O12S2
  • MW:1101.3
  • Appearance:White to Off-White Solid
  • Purity:99% (HPLC)

3

0

0

0

Product Name Qty
Quinomycin A, HIF-1 inhibitor
1 mg
$96.82
Quinomycin A, HIF-1 inhibitor
5 mg
$446.51

Quinomycin A, aka Echinomycin is a cyclic depsipeptide metabolite, Quinomycin A has broad activity against bacteria, fungi, and viruses. Also used as anti-tumor agent. Recent studies show Quniomycin A to be a potent inhibitor of Hypoxia-inducible factor-1 (HIF-1), HIF-1 plays an essential role in tumor progression metastasis. Quinomycin is toxic and possibly mutagenic, extreme caution is required when handling.

More Information
Alternate Name/Synonyms
Echinomycin, Actinoleukin, 1491, 59266, X 948, X 53III
SKU
Q-1112
CAS #
512-64-1
Chemical Name
N-(2-QUINOXALINYLCARBONYL)-O-[N-(2-QUINOXALINYLCARBONYL)-D-SERYL-L-ALANYL-3-MERCAPTO-N,S-DIMETHYLCYSTEINYL-N-METHYL-L-VALYL]-D-SERYL-L-ALANYL-N-METHYLCYSTEINYL-N-METHYL L-VALINE (81)-LACTONE CYCLIC (37)-THIOESTER
Chemical Formula
C51H64N12O12S2
Molecular Weight
1101.3
Appearance
White to Off-White Solid
Purity
99% (HPLC)
Solubility
Soluble in 100% Ethanol, Methanol, DMF, DMSO, Insoluble in Water
THERAPEUTIC AREA
Oncological Disorders
USE
Quinomycin A to induce apoptosis in human colon cancer cells (HT-29) with activity associated with cytochrome c release and stimulations of ERK and caspase-3
MDL NUMBER
MFCD00156105
CHEMACX
X1009705-7
INCHI
InChI=1S/C51H64N12O12S2/c1-25(2)38-49(72)74-22-36(59-42(65)34-21-53-30-17-13-15-19-32(30)57-34)44(67)55-28(6)46(69)63(10)40-48(71)62(9)39(26(3)4)50(73)75-23-35(58-41(64)33-20-52-29-16-12-14-18-31(29)56-33)43(66)54-27(5)45(68)60(7)37(47(70)61(38)8)24-77-51(40)76-11/h12-21,25-28,35-40,51H,22-24H2,1-11H3,(H,54,66)(H,55,67)(H,58,64)(H,59,65)/t27-,28-,35+,36+,37?,38-,39-,40?,51?/m0/s1
SMILES
C[C@H]1C(=O)N(C2CSC(C(C(=O)N([C@H](C(=O)OC[C@H](C(=O)N1)NC(=O)c3cnc4ccccc4n3)C(C)C)C)N(C(=O)[C@@H](NC(=O)[C@@H](COC(=O)[C@@H](N(C2=O)C)C(C)C)NC(=O)c5cnc6ccccc6n5)C)C)SC)C
RTECS
JW5250000
UN #'S
UN 3462
PACKING GROUP
II
Handling
Hygroscopic, Protect from Moisture. Toxic, may be Mutagenic.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
Handling Hygroscopic, Protect from Moisture. Toxic, may be Mutagenic.
UN #'S UN 3462
Packing Group II
To Top