Quinomycin A, HIF-1 inhibitor

SKU
Q-1112
  • CAS:512-64-1
  • Formula:C51H64N12O12S2
  • MW:1101.3
  • Appearance:White to Off-White Solid
  • Purity:99% (HPLC)
Product Name Qty
Quinomycin A, HIF-1 inhibitor
1 mg
$153.00
Quinomycin A, HIF-1 inhibitor
5 mg
$449.00

Description

Quinomycin A (also known as Echinomycin) is a cyclic depsipeptide metabolite, Quinomycin A has broad activity against bacteria, fungi, and viruses. Also used as anti-tumor agent.

Recent studies show Quniomycin A to be a potent inhibitor of Hypoxia-inducible factor-1 (HIF-1), HIF-1 plays an essential role in tumor progression metastasis. Quinomycin is toxic and possibly mutagenic, extreme caution is required when handling.

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Echinomycin, Actinoleukin, 1491, 59266, X 948, X 53III
SKU
Q-1112
CAS #
512-64-1
Chemical Name
N-(2-QUINOXALINYLCARBONYL)-O-[N-(2-QUINOXALINYLCARBONYL)-D-SERYL-L-ALANYL-3-MERCAPTO-N,S-DIMETHYLCYSTEINYL-N-METHYL-L-VALYL]-D-SERYL-L-ALANYL-N-METHYLCYSTEINYL-N-METHYL L-VALINE (81)-LACTONE CYCLIC (37)-THIOESTER
Chemical Formula
C51H64N12O12S2
Molecular Weight
1101.3
Appearance
White to Off-White Solid
Purity
99% (HPLC)
Solubility
Soluble in 100% Ethanol, Methanol, DMF, DMSO, Insoluble in Water
THERAPEUTIC AREA
Oncological Disorders
USE
Quinomycin A to induce apoptosis in human colon cancer cells (HT-29) with activity associated with cytochrome c release and stimulations of ERK and caspase-3
MDL NUMBER
MFCD00156105
CHEMACX
X1009705-7
INCHI
InChI=1S/C51H64N12O12S2/c1-25(2)38-49(72)74-22-36(59-42(65)34-21-53-30-17-13-15-19-32(30)57-34)44(67)55-28(6)46(69)63(10)40-48(71)62(9)39(26(3)4)50(73)75-23-35(58-41(64)33-20-52-29-16-12-14-18-31(29)56-33)43(66)54-27(5)45(68)60(7)37(47(70)61(38)8)24-77-51(40)76-11/h12-21,25-28,35-40,51H,22-24H2,1-11H3,(H,54,66)(H,55,67)(H,58,64)(H,59,65)/t27-,28-,35+,36+,37?,38-,39-,40?,51?/m0/s1
SMILES
C[C@H]1C(=O)N(C2CSC(C(C(=O)N([C@H](C(=O)OC[C@H](C(=O)N1)NC(=O)c3cnc4ccccc4n3)C(C)C)C)N(C(=O)[C@@H](NC(=O)[C@@H](COC(=O)[C@@H](N(C2=O)C)C(C)C)NC(=O)c5cnc6ccccc6n5)C)C)SC)C
RTECS
JW5250000
UN #'S
UN 3462
PACKING GROUP
II
Handling
Hygroscopic, Protect from Moisture. Toxic, may be Mutagenic.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
HandlingHygroscopic, Protect from Moisture. Toxic, may be Mutagenic.
UN #'SUN 3462
Packing GroupII
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