RNase A

SKU
R-2000
  • CAS:9001-99-4
  • Formula:C9H14N4O3
  • Appearance:White lyophilized powder
  • Purity:≥95%

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Starting at $49.99

Product Name Qty
Rnase A
100 mg
$49.99
Rnase A
10g
$1,399.99
Rnase A
250 mg
$99.99
Rnase A
500 mg
$174.99
Rnase A
1 g
$274.99

Description

RNase stands for ribonuclease, an RNA digesting enzyme. RNase consists of 124 amino acids in one polypeptide chain with 4 disulphide linkages. Ribonucleases can be divided into endoribonucleases and exoribonucleases. RNases have important roles in RNA degradation and turnover in all organisms. Ribonuclease enzyme can unwind the RNA helix by complexing with single-stranded RNA. RNase A is an endoribonuclease with functions in RNA metabolism and regulation of gene expression. It was found to play roles in diseases such as autoimmune diseases, renal insufficiencies and pancreas disorder. More recently, an antitumor activity was also reported for an RNase A with cytotoxic and cytostatic properties. The members of RNase A superfamily are widely expressed and present in serum and tissues of mammals. The ribonucleolytic activity in the pancreas of ruminants is particularly high, perhaps to digest the large amount of RNA produced by stomach microorganisms. 

 

Features & Benefits of AG Scientific's RNase A

• Chromatographically purified, salt-free, lyophilized powder
• DNase and protease free
• Cleaves at the 3'-side of the pyrimidine (uracil or cytosine) phosphate bonds
• Degrades RNA to cyclic nucleotide monophosphates to 5'-OH and 2'-,3'-cyclic monophosphate

 

Applications

The enzyme can be used to hydrolyze RNA from protein samples. It is compatible for use in RNase protection assays, to remove unspecifically bound RNA, in the analysis of RNA sequences, to hydrolyze RNA contained in protein samples, and in the purification of DNA.

Additional Reading - RNAse A: Frequently Asked Questions

 

 

More Information
Alternate Name/Synonyms
Pancreatic Ribonuclease, RNase A; Ribonucleate 3′-pyrimidinooligonucleotidohydrolase
SKU
R-2000
CAS #
9001-99-4
Chemical Name
2-(3-Aminopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid
Chemical Formula
C9H14N4O3
Molecular Weight
N/A
Appearance
White lyophilized powder
Purity
≥95%
Melting Point
N/A
Preparation
N/A
Storage Temp
Store in tightly sealed vial at -20°C. Once opened, re-desiccate over silica gel under vacuum before returning to -20˚C
THERAPEUTIC AREA
Not Applicable
USE
Ribonuclease A catalyzes the cleavage of the phosphodiester bond between the 5’-ribose of a nucleotide and the phosphate group attached to the 3’-ribose of an adjacent pyrimidine nucleotide. This cleavage forms a 2’,3’-cyclic phosphate, which is then hydrolyzed to the corresponding 3’-nucleoside phosphate.
Merck Index
N/A
MDL NUMBER
MFCD00132181
CHEMACX
X1037961-6
Handling
Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
msds 1
/media/upload/pdf/R-2000. RNase A, SDS, diamond format.pdf
Certificate of Analysis 1
/media/upload/pdf/R-2000, J1269.pdf
Certificate of Analysis 2
/media/upload/pdf/R-2000, J1237.pdf
Certificate of Analysis 3
/media/upload/pdf/R-2000, H1000B.pdf
Handling Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
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