Robotnikinin ,Shh inhibitor

SKU
R-2028
  • Formula:C25H27ClN2O4
  • MW:454.95
  • Appearance:White Solid
  • Purity:97%
Product Name Qty
Robotnikinin ,Shh inhibitor
1 mg
$307.10
Robotnikinin  | Shh inhibitor
5x1 mg
$1,242.01
A small-molecule chemical inhibitor of Sonic hedgehog (Shh) signaling, that blocks hedgehog signaling through specific binding and blockade of Shh signaling factor. It is the first characterized hedgehog inhibitor whose molecular mechanism of action is through blockade of Shh protein and not a factor of the hedgehog signaling cascades.Robotnikinin binds to the Shh-N terminal protein in a concentration-dependent fashion with a K of 9M.Robotnikinin is an embryogenesis inhibitor such as in the growth in digits on limbs and organization of the brain. Morphogenetic activity, Shh signaling is centrally responsible in the ventral portion of the neural tube and the induction of floor plate cells and motor neurons.Robotbikinin, an inhibitor of the Hedgehog signaling pathway, has been found and dubbed 'Robotnikinin'.
More Information
Alternate Name/Synonyms
N-[(Chlorophenyl)methyl]-2-[2R,6S,8E)-5, 12-Dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-6-yl]acetamide
SKU
R-2028
Chemical Name
N-[(Chlorophenyl)methyl]-2-[2R,6S,8E)-5, 12-Dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-6-yl]acetamide
Chemical Formula
C25H27ClN2O4
Molecular Weight
454.95
Appearance
White Solid
Purity
97%
Solubility
Soluble in DMSO
Storage Temp
-20°C
THERAPEUTIC AREA
Not Available
USE
Not Available
MDL NUMBER
Not Available
CHEMACX
X5334459-9
INCHI
InChI=1S/C25H27ClN2O4/c26-21-13-11-18(12-14-21)16-27-23(29)15-20-9-5-2-6-10-24(30)32-22(17-28-25(20)31)19-7-3-1-4-8-19/h1-5,7-8,11-14,20,22H,6,9-10,15-17H2,(H,27,29)(H,28,31)/b5-2-/t20-,22-/m0/s1
SMILES
C1CC(=O)O[C@@H](CNC(=O)[C@@H](C/C=C1)CC(=O)NCC2=CC=C(C=C2)Cl)C3=CC=CC=C3
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from moisture. Do not take internally. Wear gloves and mask.
Certificate of Analysis 1
Certificate of Analysis 2
Promo text for AGS discount
N/A
Handling Protect from moisture. Do not take internally. Wear gloves and mask.
UN #'S Not Applicable
Packing Group Not Applicable
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