Description

Vancomycin HCl is a glycopeptide antibiotic that inhibits the growth of gram-positive microorganisms, such as MRSA (methicillin-resistant Staphylococcus aureus.) It is isolated from Streptomyces orientalis and was first discovered within a soil sample found in Borneo in 1953. Vancomycin hydrochloride interferes with microbial cell wall synthesis by inhibiting the incorporation of terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides. Vancomycin is often used with cefotaxime (C-1463) or carbenicillin (C-1385) to produce a wide spectrum of activity against both Gram-positive and Gram-negative bacteria.

Applications

• Treatment of severe infections caused by strains of methicillin-resistant (β-lactam-resistant) staphylococci.
• Blocks bacterial cell wall synthesis
• Studies involving cancer patients
• Studies on antibiotic resistance
• Nanoparticle transport studies

Specifications

• Vancomycin HCl is commonly used in concentrations in the range of 50-100 μg/ml. Potency: >1,000 μg per mg.
• EC Number: 604-193-8