Venturicidin B, Streptomyces sp.

SKU
V-1070
  • CAS:33538-72-6
  • Formula:C40H66O10
  • MW:707
  • Appearance:White Lyophilisate
  • Purity:95% by HPLC

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Product Name Qty
Venturicidin B, Streptomyces sp.
0.25 mg
$253.86
Venturicidin B, Streptomyces sp.
1 mg
$827.81

The macrolide antibiotic Venturicidin B, isolated from a Streptomyces sp., is a potent inhibitor of mitochondrial ATP synthase complex actin. Specifically, venturicidin is a FO ATP synthase inhibitor. F0F1-ATPases (ATP synthases) are the oligomeric molecular machines that couple ATP hydrolysis with proton translocation across the energy-transducing membranes in mitochondria, chloroplasts, and bacteria. Venturicidin B was originally isolated as an antifungal agent.

More Information
Alternate Name/Synonyms
Aabomycin A2
SKU
V-1070
CAS #
33538-72-6
Chemical Name
(1R,5S,6R,8R,9E,11R,15E,17R)-11-[(2R,4R,6R)-4,5-DIHYDROXY-6-METHYL-TETRAHYDROPYRAN-2-YL]OXY-1-HYDROXY-5-[(1R,3R,4S,5S)-4-HYDROXY-1,3,5-TRIMETHYL-6-OXO-OCTYL]-6,8,16,18-TETRAMETHYL-4,21-DIOXABICYCLO[15.3.1]HENICOSA-9,15,18-TRIEN-3-ONE
Chemical Formula
C40H66O10
Molecular Weight
707
Appearance
White Lyophilisate
Purity
95% by HPLC
Solubility
Soluble in ethanol, methanol, DMF or DMSO
Melting Point
145-149 °C
Storage Temp
+4°C
THERAPEUTIC AREA
Infectious Diseases
USE
The macrolide antibiotic Venturicidin B, isolated from a Streptomyces bacteria, is a potent inhibitor of mitochondrial ATP synthase complex acting on the F0 membrane sector
MDL NUMBER
MFCD08061904
CHEMACX
X6952280-5
INCHI
InChI=1S/C40H66O10/c1-10-32(41)29(8)36(44)26(5)20-28(7)38-27(6)19-23(2)15-16-31(48-35-21-33(42)37(45)30(9)47-35)14-12-11-13-24(3)39-25(4)17-18-40(46,50-39)22-34(43)49-38/h13,15-17,23,26-31,33,35-39,42,44-46H,10-12,14,18-22H2,1-9H3/b16-15+,24-13+/t23-,26+,27+,28+,29+,30+,31+,33+,35-,36-,37?,38-,39+,40+/m0/s1
SMILES
CCC(=O)[C@@H](C)[C@H]([C@H](C)C[C@@H](C)[C@@H]1[C@@H](C[C@H](/C=C/[C@@H](CCC/C=C(/[C@@H]2C(=CC[C@@](O2)(CC(=O)O1)O)C)C)O[C@H]3C[C@H](C([C@H](O3)C)O)O)C)C)O
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
UN #'S Not Applicable
Packing Group Not Applicable
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