Venturicidin B

SKU
V-1070
  • CAS:33538-72-6
  • Formula:C40H66O10
  • MW:707
  • Appearance:White Lyophilisate
  • Purity:>95% by HPLC

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1

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Product Name Qty
Venturicidin B, Streptomyces sp.
0.25 mg
$253.86
Venturicidin B, Streptomyces sp.
1 mg
$827.81

Description

The macrolide antibiotic Venturicidin B, isolated from a Streptomyces sp. is a potent inhibitor of mitochondrial ATP synthase complex actin. Specifically, venturicidin is a FO ATP synthase inhibitor. ATP synthases are the oligomeric molecular machines that couple ATP hydrolysis with proton translocation across the energy-transducing membranes in mitochondria, chloroplasts, and bacteria. 

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Aabomycin A2
SKU
V-1070
CAS #
33538-72-6
Chemical Name
(1R,5S,6R,8R,9E,11R,15E,17R)-11-[(2R,4R,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-1-hydroxy-5-[(2R,4R,5S,6S)-5-hydroxy-4,6-dimethyl-7-oxononan-2-yl]-6,8,16,18-tetramethyl-4,21-dioxabicyclo[15.3.1]henicosa-9,15,18-trien-3-one
Chemical Formula
C40H66O10
Molecular Weight
707
Appearance
White Lyophilisate
Purity
>95% by HPLC
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Storage Temp
-20°C
THERAPEUTIC AREA
Infectious Diseases
USE
The macrolide antibiotic Venturicidin B, isolated from a Streptomyces bacteria, is a potent inhibitor of mitochondrial ATP synthase complex acting on the F0 membrane sector
MDL NUMBER
MFCD08061904
CHEMACX
X6952280-5
INCHI
InChI=1S/C40H66O10/c1-10-32(41)29(8)36(44)26(5)20-28(7)38-27(6)19-23(2)15-16-31(48-35-21-33(42)37(45)30(9)47-35)14-12-11-13-24(3)39-25(4)17-18-40(46,50-39)22-34(43)49-38/h13,15-17,23,26-31,33,35-39,42,44-46H,10-12,14,18-22H2,1-9H3/b16-15+,24-13+/t23-,26+,27+,28+,29+,30+,31+,33+,35-,36-,37?,38-,39+,40+/m0/s1
SMILES
CCC(=O)[C@@H](C)[C@H]([C@H](C)C[C@@H](C)[C@@H]1[C@@H](C[C@H](/C=C/[C@@H](CCC/C=C(/[C@@H]2C(=CC[C@@](O2)(CC(=O)O1)O)C)C)O[C@H]3C[C@H](C([C@H](O3)C)O)O)C)C)O
Handling
Handle in accordance with good industrial hygiene and safety practice.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
Handling Handle in accordance with good industrial hygiene and safety practice.
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