A23187, Free Acid
- Appearance:White Powder
Starting at $78.34
A23187 (calcimycin) is a carboxylic acid antibiotic derived from cultures of Streptomyces chartreusensis that transports divalent cations across cell membranes, which are usually impermeable to them. This mobile Ion - carrier forms stable complexes with divalent cations (ions with a charge of +2).
The ionophore is used in laboratories to increase intracellular Ca2+ levels in intact cells. A23187 has antibiotic properties against Gram-positive bacteria and fungi. A23187 also induces apoptosis in some cells (e.g. mouse lymphoma cell line, or S49, and Jurkat cells). Recent clinical studies indicate that treatment of oocytes lacking a 2ndPb with A23187 at 4.5–5.0 h after ICSI (Intracytoplasmic sperm injection) is expected to be effective at preventing fertilization failure.
Not for human therapeutic use or for medicinal purposes. For research applications only.
|Handling||Warning.Toxic. May be Carcinogenic. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Protect from Light Protect from Moisture.|
|UN #'S||Not Applicable|
|Packing Group||Not Applicable|