A23187, Free Acid

SKU
A-1020
  • CAS:52665-69-7
  • Formula:C29H37N3O6
  • MW:523.6
  • Appearance:White Powder
  • Purity:98%

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Starting at $78.34

Product Name Qty
A23187, Free Acid
50 mg
$536.08
A23187, Free Acid
5 mg
$78.34
A23187, Free Acid
10 mg
$134.84

A23187 is a carboxylic acid antibiotic derived from cultures of Streptomyces chartreusensis that transports divalent cations across cell membranes, which are usually impermeable to them. This mobile Ion - carrier  forms stable complexes with divalent cations (ions with a charge of +2). The ionophore is used in laboratories to increase intracellular Ca2+ levels in intact cells. A23187 has antibiotic properties against gram-positive Bacteria and fungi.  A23187 also induces apoptosis in some cells (e.g. mouse lymphoma cell line, or S49, and Jurkat cells). Recent clinical studies indicate that treatment of oocytes lacking a 2ndPb with A23187 at 4.5–5.0 h after ICSI (Intracytoplasmic sperm injection) is expected to be effective at preventing fertilization failure.

More Information
Alternate Name/Synonyms
Calcium Ionophore A23187, Calcimycin, Antibiotic A23187, Calcium Ionophore
SKU
A-1020
CAS #
52665-69-7
Chemical Name
5-(METHYLAMINO)-2-[(2R,3R,6S,8S,9R,11R)-3,9,11-TRIMETHYL-8-[(1S)-1-METHYL-2-OXO-2-(1H-PYRROL-2-YL)-ETHYL]-1,7-[DIOXASPIRO[5.5]UNDEC-2-YL]METHYL]-4-BENZOXAZOLECARBOXYLIC ACID
Chemical Formula
C29H37N3O6
Molecular Weight
523.6
Appearance
White Powder
Purity
98%
Solubility
Soluble in Methanol and Acetic Acid
Melting Point
190°C
Preparation
N/A
Storage Temp
Store at -20°C
THERAPEUTIC AREA
Infectious Diseases
USE
A23187 has antibiotic properties against gram positive bacteria and fungi
Merck Index
N/A
MDL NUMBER
MFCD00151202
CHEMACX
X1001942-8
INCHI
InChI=1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16+,17+,18?,22-,27-,29?/m0/s1
SMILES
C[C@H]1CCC2([C@@H](C[C@H]([C@H](O2)C(C)C(=O)c3ccc[nH]3)C)C)O[C@H]1Cc4nc5c(o4)ccc(c5C(=O)O)NC
Peptide sequence
Not Applicable
RTECS
DM4676000
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Warning.Toxic. May be Carcinogenic. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Protect from Light Protect from Moisture.
Citations
MECHANISMS OF SIGNAL TRANSDUCTION: Identification of Nitric Oxide as an Endogenous Activator of the AMP-activated Protein Kinase in Vascular Endothelial Cells Junhua Zhang, Zhonglin Xie, Yunzhou Dong, Shuangxi Wang, Chao Liu, and Ming-Hui Zou J. Biol. Chem., Oct 2008; 283: 27452 - 27461.
Citations_Hyperlink
http://www.jbc.org/cgi/reprint/283/41/27452
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Warning.Toxic. May be Carcinogenic. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Protect from Light Protect from Moisture.
UN #'S Not Applicable
Packing Group Not Applicable
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