Carnosic Acid

SKU
C-1213
  • CAS:3650-09-7
  • Formula:C20H28O4
  • MW:332.44 Da
  • Appearance:Off white to yellow powder
  • Purity:≥99% (HPLC)

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Product Name Qty
Carnosic acid
10 mg
$58.74
Carnosic acid
50 mg
$184.37

Carnosic acid (CA), the main antioxidant compound of Rosmarinus officinalis - Rosemary extract, has been shown to display anticancer activity. CA Inhibits lipid peroxidation induced by NADH or NADPH oxidation. CA induced apoptosis in HCT116 cells via generation of ROS, induction of p53, activation of caspases and inhibition of STAT3 signaling pathway. 

Carnosic acid is also a compound of the crude extract from Oregano (Origanum Vulgare). A recent study conducted by researchers in Brazil using this extract have demonstrated significant virucidal activity against equine arteritis virus. CA is a diterpenoid, that has anti-inflammatory effects. Recently researchers have shown that CA along with another diterpenoid - Carnosol (CS) exert anti-infalmmatory effects by inhibiting 2 key enzymes of inflammation. 5-LO and mPEGS-1 are the two key enzymes of inflammation that are the primary targets of CA and CS. In food industry CA from rosemary extract is incorporated into food formulations to increase shelf life of food and beverages.

 

More Information
Alternate Name/Synonyms
Salvin; RoseOx; (4aR,10aS)-5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-1,3,4,9,10,10a-hexahydro-2H-phenanthrene-4a-carboxylic acid
SKU
C-1213
CAS #
3650-09-7
Chemical Name
(4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid
Chemical Formula
C20H28O4
Molecular Weight
332.44 Da
Appearance
Off white to yellow powder
Purity
≥99% (HPLC)
Solubility
Soluble in DMSO (50 mg/mL)
Melting Point
N/A
Preparation
N/A
Storage Temp
-20°C, desiccated, store up to 1 month.
THERAPEUTIC AREA
Oncological Disorders
USE
Inhibitory effects of rosemary extracts, carnosic acid on the growth of various human cancer cell. Carnosic acid is a diterpenoid that acts as an effective lipid peroxidation inhibitor in liposomal and microsomal environments, with antioxidant properties. Carnosic acid has been reported to scavenge peroxyl radicals, H2O2, reduce cytochrome C, and act more potently than Propyl gallate (sc-250794). Studies indicate that Carnosic acid protects red cells from oxidative hemolysis and in the xanthine/xanthine oxidase system inhibits superoxide anion production.
Merck Index
N/A
MDL NUMBER
MFCD02259459
CHEMACX
X1341163-5
INCHI
InChI=1S/C20H28O4/c1-11(2)13-10-12-6-7-14-19(3,4)8-5-9-20(14,18(23)24)15(12)17(22)16(13)21/h10-11,14,21-22H,5-9H2,1-4H3,(H,23,24)/t14-,20+/m0/s1
SMILES
CC(C)c1cc2c(c(c1O)O)[C@]3(CCCC([C@@H]3CC2)(C)C)C(=O)O
Handling
Protect from light. Ensure adequate ventilation, especially in confined areas. Use personal protective equipment as required. Use with local exhaust ventilation. Do not breathe dust/fume/gas/mist/vapors/spray.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
Handling Protect from light. Ensure adequate ventilation, especially in confined areas. Use personal protective equipment as required. Use with local exhaust ventilation. Do not breathe dust/fume/gas/mist/vapors/spray.
Citations “Obtenção de extrato de alecrim (Rosmarinus officinalis) por extração supercrítica: determinação do rendimento global, de parâmetros cinéticos e de equilíbrio e outras variáveis do processo”
Inhibitory effects of rosemary extracts, carnosic acid and rosmarinic acid on the growth of various human cancer cell lines
Screening of free radical scavenging capacity and antioxidant activities of Rosmarinus officinalis extracts with focus on location and harvesting times
Avaliação do potencial antioxidante de extratos ativos de plantas obtidos por extração com fluido supercrítico
Modulation of ARTS and XIAP by Parkin Is Associated with Carnosic Acid Protects SH-SY5Y Cells against 6-Hydroxydopamine-Induced Apoptosis
Carnosic acid protects SH-SY5Y cells against 6-hydroxydopamine-induced cell death through upregulation of parkin pathway
PINK1/parkin-mediated mitophagy pathway is related to neuroprotection by carnosic acid in SH-SY5Y cells
Microenvironmental networks promote tumor heterogeneity and enrich for metastatic cancer stem-like cells in Luminal-A breast tumor cells
Carnosic acid promotes degradation of the androgen receptor and is regulated by the unfolded protein response pathway in vitro and in vivo
A kinetic model for evaluation of the antioxidant activity of several rosemary extracts
Effectiveness of natural versus synthetic antioxidants in a rice bran oil-based structured lipid
Relevance of carnosic acid concentrations to the selection of rosemary, Rosmarinus officinalis (L.), accessions for optimization of antioxidant yield
Cytotoxic responses of carnosic acid and doxorubicin on breast cancer cells in butterfly-shaped microchips in comparison to 2D and 3D culture
The protective role of carnosic acid against beta-amyloid toxicity in rats
Oxidative stability, characterization and food applications of a rice bran oil-based structured lipid
In vitro antioxidant activities of Rosmarinus officinalis extracts treated with supercritical carbon dioxide
Relevance of phenolic diterpene constituents to antioxidant activity of supercritical CO(2) extract from the leaves of rosemary
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