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Carnosol

SKU
C-1211
  • CAS:5957-80-2
  • Formula:C20H26O4
  • MW:330.4 Da
  • Appearance:Crystalline Solid
  • Purity:≥96%

2

1

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SDS
CofA
Product Name Qty
Carnosol
1 mg
$78.60
Carnosol
5 mg
$332.60
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Description

Carnosol is a naturally occurring phenolic compound found in rosemary with antioxidant and anticarcinogenic activity. It inhibits the formation of tumors in mouse models or carcinogenesis derived by irritants such as TPA and DMBA and inductions of COX-2 by blocking PKC signaling. It has strong dose-dependent inhibitory effects against RSK2 (Ribosomal S6 Kinase) by suppressing its autophosphorylation, therefore, it shows anticancer property.

It also causes a significant decrease in both bacterial and yeast growth.

 

Application

• Antioxidant

• Antimicrobial

• Anticarcinogen

 

References

• “Carnosol: A promising anti-cancer and anti-inflammatory agent”

• “Antimicrobial activity of Carnosol and Ursolic acid: two anti-oxidant constituents of Rosmarinus officinalis L” 

  

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Picrosalvin
SKU
C-1211
CAS #
5957-80-2
Chemical Name
(1R,8S,10S)-3,4-dihydroxy-11,11-dimethyl-5-propan-2-yl-16-oxatetracyclo[6.6.2.01,10.02,7]hexadeca-2,4,6-trien-15-one
Chemical Formula
C20H26O4
Molecular Weight
330.4 Da
Appearance
Crystalline Solid
Purity
≥96%
Solubility
Soluble in DMSO @ 25 mg/ml or Ethanol @ 8 mg/ml
Melting Point
210-220 °C
Storage Temp
-20°C, desiccated, keep cool and dry
THERAPEUTIC AREA
Oncological Disorders
USE
Carnosol is a naturally occurring phytopolyphenol found in rosemary. Carnosol functions as antioxidant and anticarcinogen. Carnosol has been shown to inhibit inductions of COX-2 by blocking PKC signaling. Carnosol is an inhibitor of AR and ER α.
MDL NUMBER
MFCD02752467
CHEMACX
X1463260-5
INCHI
InChI=1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1
SMILES
CC(C)c1cc2c(c(c1O)O)[C@@]34CCCC([C@@H]3C[C@@H]2OC4=O)(C)C
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Avoid contact with skin, eyes or clothing. Wash contaminated clothing before reuse. Do not eat, drink or smoke when using this product. Use personal protective equipment as required. Do not breathe dust/fume/gas/mist/vapors/spray. Use with local exhaust ventilation. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
msds 1
C-1211, Carnosol, SDS, diamond format.pdf
Certificate of Analysis 1
C-1211, L1025.pdf
Certificate of Analysis 2
C-1211, F1115C.pdf
Certificate of Analysis 3
C-1211, F1115B.pdf
GHS PICTOGRAMS
Handling Avoid contact with skin, eyes or clothing. Wash contaminated clothing before reuse. Do not eat, drink or smoke when using this product. Use personal protective equipment as required. Do not breathe dust/fume/gas/mist/vapors/spray. Use with local exhaust ventilation. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
UN #'S Not Applicable
Packing Group Not Applicable
Citations Inhibition of heterocyclic amine formation in beef patties by ethanolic extracts of rosemary
Effect of Marinades on the Formation of Heterocyclic Amines in Grilled Beef Steaks
Production of phenolic diterpenes in tissue culture of Rosmarinus officinalis L.
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