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E-64

SKU
E-2030
  • CAS:66701-25-5
  • Formula:C15H27N5O5
  • MW:357.4 Da
  • Appearance:White powder
  • Purity:≥99%
Product Name Qty
E-64
5 mg
$102.30
E-64
25 mg
$496.16
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Description

E-64 is an Irreversible, potent and highly selective inhibitor of cysteine proteases. It does not affect cysteine residues in other enzymes. E64 acts by forming a thioether bond with the thiol of the active cysteine. E-64 will not inhibit serine proteases (except trypsin) but inhibits activation-induced programmed cell death and restores defective immune responses in HIV. Specific active site titrant.

Applications

• Used as an inhibitor for calpain, papain, and cathepsin B, cathepsin L
• Used to study excystation in Giardia lamblia
• Used to reduce inflammation in cystic fibrosis patients

 

More Information
Alternate Name/Synonyms
Thiol protease inhibitor
SKU
E-2030
CAS #
66701-25-5
Chemical Name
(2S,3S)-3-[[(2S)-1-[4-(diaminomethylideneamino)butylamino]-4-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acid
Chemical Formula
C15H27N5O5
Molecular Weight
357.4 Da
Appearance
White powder
Purity
≥99%
Solubility
Up to 20mg/ml in water, Up to 25mg/ml in DMSO
Storage Temp
-20°C, desiccated
USE
E-64 is a broad spectrum cysteine proteinase and calpain activation inhibitor. E-64 has been reported to inhibit intracellular cathepsin B, cathepsin L, cathepsin H, Bax protease activity, and reduces oxidative stress, which includes a decrease in MDA levels, ICAM-1 expression and MOP acitivity. Additionally, Prevotella intermedia studies report that E-64 blocks the breakdown of methaemoglobin and the oxidation of oxyhaemoglobin by InpA. E-64 has also been used to study excystation in Giardia lamblia. E-64 is an inhibitor of Calpain, cathepsin K and cathepsin S.
MDL NUMBER
MFCD00080261
CHEMACX
X1036521-8
PubChecm ID
123985
INCHI
LTLYEAJONXGNFG-DCAQKATOSA-N
SMILES
CC(C)CC(C(=O)NCCCCN=C(N)N)NC(=O)C1C(O1)C(=O)O
RTECS
RR0390000
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation. Handle in accordance with good industrial hygiene and safety practice. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
Citations
α-Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junction Vivian W. Tang and William M. Brieher J. Cell Biol., Jan 2012; 196: 115 - 130.
Citations_Hyperlink
http://jcb.rupress.org/cgi/reprint/196/1/115
msds 1
E-2030, E-64, SDS, diamond format, r01, 2020.pdf
Certificate of Analysis 1
E-2030, L1105A.pdf
Certificate of Analysis 2
E-2030, K1265C.pdf
Certificate of Analysis 3
E-2030, J1210.pdf
GHS PICTOGRAMS
HandlingAvoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation. Handle in accordance with good industrial hygiene and safety practice. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
CitationsHost Plants Indirectly Influence Plant Virus Transmission by Altering Gut Cysteine Protease Activity of Aphid Vectors
Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor
Crystal Structure of an LSD-Bound Human Serotonin Receptor
The multifunctional autophagy pathway in the human malaria parasite, Plasmodium falciparum
Transcytosis of HIV-1 through vaginal epithelial cells is dependent on trafficking to the endocytic recycling pathway
CHARACTERIZATION OF SMOOTH MUSCLE CELL PHENOTYPE AND FUNCTIONALITY FOR POTENTIAL TISSUE ENGINEERING APPLICATIONS
Mature viral cathepsin is required for release of viral occlusion bodies from Autographa californica multiple nucleopolyhedrovirus-infected cells
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