MG-132, also known as Z-Leu-leu-leu-al, is a potent, cell-permeable, reversible, and selective 26S proteasome inhibitor and calpain inhibitor. The inhibitor is used to interfere with degradation of intracellular proteins involved in inflammatory processes and cell cycle regulation. The proteasome inhibitor reduces the degradation of IkBa, and thus it inhibits TNF-a induced NF-kB activation.
MG-132 has anticancer properties. It activates c-Jun N-terminal kinase (JNK1), initiating apoptosis. It also affects various human cancer cell lines irrespective of their p53 status and is more effective in combination with drugs such as doxorubicin and etoposide.
This inhibitor induces neurite outgrowth in PC 12 cells and acts as an autophagy in MCF-7 cells. It has been reported that MG-132-induced autophagy is related to endoplasmic reticulum (ER) stress.
• 26S proteasome inhibitor
• Calpain inhibitor
• Anticancer reagent
Not for human therapeutic use or for medicinal purposes. For research applications only.
|Handling||Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.|