• CAS:133407-82-6
  • Formula:C26H41N3O5
  • MW:475.6 Da
  • Appearance:White powder
  • Purity:≥98%

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Product Name Qty
1 mg
5 mg


MG-132, also known as Z-Leu-leu-leu-al, is a potent, cell-permeable, reversible, and selective 26S proteasome inhibitor and calpain inhibitor. The inhibitor is used to interfere with degradation of intracellular proteins involved in inflammatory processes and cell cycle regulation. The proteasome inhibitor reduces the degradation of IkBa, and thus it inhibits TNF-a induced NF-kB activation.

MG-132 has anticancer properties. It activates c-Jun N-terminal kinase (JNK1), initiating apoptosis. It also affects various human cancer cell lines irrespective of their p53 status and is more effective in combination with drugs such as doxorubicin and etoposide.

This inhibitor induces neurite outgrowth in PC 12 cells and acts as an autophagy in MCF-7 cells. It has been reported that MG-132-induced autophagy is related to endoplasmic reticulum (ER) stress.



• 26S proteasome inhibitor

• Calpain inhibitor

• Anticancer reagent



• “Potential of the proteasomal inhibitor MG-132 as an anticancer agent, alone and in combination.”

• “Induction of autophagy by the MG‑132 proteasome inhibitor is associated with endoplasmic reticulum stress in MCF‑7 cells”

• “Inhibition of TNF- α -induced NF- κ B Activation and IL-8 Release in A549 Cells with the Proteasome Inhibitor MG-132”


Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Z-Leu-leu-leu-al; Z-Leu-Leu-Leu-CHO; Z-LLL-CHO; Cbz-Leu-Leu-Leu-H
Chemical Name
Chemical Formula
Molecular Weight
475.6 Da
White powder
45 mg/mL in DMSO, 45 mg/mL in DMF, 45 mg/mL in Ethanol.
Storage Temp
-20°C, desiccated
Not Available
MG-132 is a potent, reversible, and cell-permeable proteasome inhibitor, used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. These proteins processed by the proteasome are involved in inflammatory processes and cell cycle regulation, presenting broad relevance for aldehydic proteasome inhibitors of this type. For instance, MG-132 suppresses NF-κB activation (at 10 μM) by preventing IκB degradation (IC50=3 μM), which blocks the transcription factor from providing chemoresistance to cancer cells. Also, it has been shown to prevent beta-secretase cleavage of amyloid precursor protein (APP). Additionally, MG-132 is an inhibitor of 26S Proteasome and calpain, as well as, an activator of JNK1, c-Jun and c-Fos.
Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
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HandlingUse only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
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