MG-132

SKU
M-1157
  • CAS:133407-82-6
  • Formula:C26H41N3O5
  • MW:475.6 Da
  • Appearance:White powder
  • Purity:≥98%

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Starting at $16.76

Product Name Qty
MG-132
1 mg
$16.76
MG-132
5 mg
$61.42

MG-132 is a cell permeable reversible proteosome inhibitor. MG-132 is also called as carbobenzoxy-L-leucyl-L-leucyl-L-leucinal, Z-LLL-CHO, is a peptide aldehyde, part of a group of chemicals capable of inhibiting proteases, such as serine proteases and calpain etc. MG-132 reduces the degradation of IκB (inhibitory κB), GRK2 (G-protein-receptor kinase 2), ARC (apoptosis repressor with caspase recruitment domain), and HSP (heat shock proteins), all of which exert beneficial effects on acute myocardial ischemia. Moderate proteasome inhibition by MG132 results in the upregulation of anti-oxidative enzymes, and it protects rat myocytes against H2O2-mediated oxidative stress. It also inhibits 5-lipoxygenase that selectively disrupts function of c-Myc in cancer cells and NF- κB activation.

More Information
Alternate Name/Synonyms
Z-Leu-leu-leu-al; Z-Leu-Leu-Leu-CHO; Z-LLL-CHO; Cbz-Leu-Leu-Leu-H
SKU
M-1157
CAS #
133407-82-6
Chemical Name
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
Chemical Formula
C26H41N3O5
Molecular Weight
475.6 Da
Appearance
White powder
Purity
≥98%
Solubility
45 mg/mL in DMSO, 45 mg/mL in DMF, 45 mg/mL in Ethanol.
Melting Point
N/A
Preparation
N/A
Storage Temp
-20°C, desiccated
THERAPEUTIC AREA
Not Available
USE
MG-132 is a potent, reversible, and cell-permeable proteasome inhibitor, used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. These proteins processed by the proteasome are involved in inflammatory processes and cell cycle regulation, presenting broad relevance for aldehydic proteasome inhibitors of this type. For instance, MG-132 suppresses NF-κB activation (at 10 μM) by preventing IκB degradation (IC50=3 μM), which blocks the transcription factor from providing chemoresistance to cancer cells. Also, it has been shown to prevent beta-secretase cleavage of amyloid precursor protein (APP). Additionally, MG-132 is an inhibitor of 26S Proteasome and calpain, as well as, an activator of JNK1, c-Jun and c-Fos.
Merck Index
N/A
RTECS
N/A
Handling
Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
msds 1
/media/upload/pdf/M-1157, MG-132, SDS, diamond format.pdf
Certificate of Analysis 1
/media/upload/pdf/M-1157, J1223A.pdf
Certificate of Analysis 2
/media/upload/pdf/M-1157, J1223.pdf
Certificate of Analysis 3
/media/upload/pdf/M-1157, H1285D.pdf
GHS PICTOGRAMS
Handling Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
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