Search
My Cart

MG-132

SKU
M-1157
  • CAS:133407-82-6
  • Formula:C26H41N3O5
  • MW:475.6 Da
  • Appearance:White powder
  • Purity:≥98%

0

1

0

SDS
CofA
Product Name Qty
MG-132
1 mg
$16.76
MG-132
5 mg
$61.42
Add to Compare Email
Loading...

MG-132 is a cell permeable reversible proteosome inhibitor. MG-132 is also called as carbobenzoxy-L-leucyl-L-leucyl-L-leucinal, Z-LLL-CHO, is a peptide aldehyde, part of a group of chemicals capable of inhibiting proteases, such as serine proteases and calpain etc. MG-132 reduces the degradation of IκB (inhibitory κB), GRK2 (G-protein-receptor kinase 2), ARC (apoptosis repressor with caspase recruitment domain), and HSP (heat shock proteins), all of which exert beneficial effects on acute myocardial ischemia. Moderate proteasome inhibition by MG132 results in the upregulation of anti-oxidative enzymes, and it protects rat myocytes against H2O2-mediated oxidative stress. It also inhibits 5-lipoxygenase that selectively disrupts function of c-Myc in cancer cells and NF- κB activation.

More Information
Alternate Name/Synonyms
Z-Leu-leu-leu-al; Z-Leu-Leu-Leu-CHO; Z-LLL-CHO; Cbz-Leu-Leu-Leu-H
SKU
M-1157
CAS #
133407-82-6
Chemical Name
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
Chemical Formula
C26H41N3O5
Molecular Weight
475.6 Da
Appearance
White powder
Purity
≥98%
Solubility
45 mg/mL in DMSO, 45 mg/mL in DMF, 45 mg/mL in Ethanol.
Melting Point
N/A
Preparation
N/A
Storage Temp
-20°C, desiccated
THERAPEUTIC AREA
Not Available
USE
MG-132 is a potent, reversible, and cell-permeable proteasome inhibitor, used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. These proteins processed by the proteasome are involved in inflammatory processes and cell cycle regulation, presenting broad relevance for aldehydic proteasome inhibitors of this type. For instance, MG-132 suppresses NF-κB activation (at 10 μM) by preventing IκB degradation (IC50=3 μM), which blocks the transcription factor from providing chemoresistance to cancer cells. Also, it has been shown to prevent beta-secretase cleavage of amyloid precursor protein (APP). Additionally, MG-132 is an inhibitor of 26S Proteasome and calpain, as well as, an activator of JNK1, c-Jun and c-Fos.
Merck Index
N/A
RTECS
N/A
Handling
Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
msds 1
M-1157, MG-132, SDS, diamond format.pdf
Certificate of Analysis 1
M-1157, J1223A.pdf
Certificate of Analysis 2
M-1157, J1223.pdf
Certificate of Analysis 3
M-1157, H1285D.pdf
GHS PICTOGRAMS
Handling Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
Citations AMPK-SKP2-CARM1 signalling cascade in transcriptional regulation of autophagy
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1
PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response
Activity-dependent growth of new dendritic spines is regulated by the proteasome
The Sumo-targeted ubiquitin ligase RNF4 regulates the localization and function of the HTLV-1 oncoprotein Tax
COMP-Ang1 stimulates HIF-1α-mediated SDF-1 overexpression and recovers ischemic injury through BM-derived progenitor cell recruitment
Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells
USP35 regulates mitotic progression by modulating the stability of Aurora B
Ubiquitination and degradation of the FADD adaptor protein regulate death receptor-mediated apoptosis and necroptosis
Mechanical cue-induced YAP instructs Skp2-dependent cell cycle exit and oncogenic signaling
G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis
Src-Induced cisplatin resistance mediated by cell-to-cell communication
Prolonged prometaphase blocks daughter cell proliferation despite normal completion of mitosis
The N-Terminal UND Motif of the Arabidopsis U-Box E3 Ligase PUB18 Is Critical for the Negative Regulation of ABA-Mediated Stomatal Movement and Determines Its Ubiquitination Specificity for Exocyst Subunit Exo70B1
The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation
Cleavage of phospholipase D1 by caspase promotes apoptosis via modulation of the p53-dependent cell death pathway
USP11-dependent selective cIAP2 deubiquitylation and stabilization determine sensitivity to Smac mimetics
Ubiquitylation and degradation of adenomatous polyposis coli by MKRN1 enhances Wnt/β-catenin signaling
AtAIRP2 E3 Ligase Affects ABA and High-Salinity Responses by Stimulating Its ATP1/SDIRIP1 Substrate Turnover
PTEN phosphorylation and nuclear export mediate free fatty acid-induced oxidative stress
Ubiquitination-deubiquitination balance dictates ligand-stimulated PTHR sorting
β-Catenin-Gli1 interaction regulates proliferation and tumor growth in medulloblastoma
A mechanistic study of proteasome inhibition-induced iron misregulation in dopamine neuron degeneration
Cellular determinants of hepatitis C virus assembly, maturation, degradation, and secretion
Identification of a tissue-selective heat shock response regulatory network
Novel interactions between actin and the proteasome revealed by complex haploinsufficiency
Covalent ISG15 conjugation to CHIP promotes its ubiquitin E3 ligase activity and inhibits lung cancer cell growth in response to type I interferon
High glucose-induced p53 phosphorylation contributes to impairment of endothelial antioxidant system
Targeting the degradation of AXL receptor tyrosine kinase to overcome resistance in gefitinib-resistant non-small cell lung cancer
Injury-induced platelet-derived growth factor receptor-alpha expression mediated by interleukin-1beta (IL-1beta) release and cooperative transactivation by NF-kappaB and ATF-4: IL-1beta facilitates HDAC-1/2 dissociation from promoter
Binding of MG132 or deletion of the Thr active sites in HslV subunits increases the affinity of HslV protease for HslU ATPase and makes this interaction nucleotide-independent
Docosahexaenoic acid-mediated protein aggregates may reduce proteasome activity and delay myotube degradation during muscle atrophy in vitro
The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5
Differential regulation of apoptosis by caspase-mediated cleavage of phospholipase D isozymes
Functional characterization of phytochrome autophosphorylation in plant light signaling
Structural alteration in the pore motif of the bacterial 20S proteasome homolog HslV leads to uncontrolled protein degradation
Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action
Leucine-Rich Repeat Kinase 2 (LRRK2) Stimulates IL-1β-Mediated Inflammatory Signaling through Phosphorylation of RCAN1
C-terminus of HSC70-Interacting Protein (CHIP) Inhibits Adipocyte Differentiation via Ubiquitin- and Proteasome-Mediated Degradation of PPARγ
CHFR negatively regulates SIRT1 activity upon oxidative stress
Site-specific polyubiquitination differentially regulates parathyroid hormone receptor-initiated MAPK signaling and cell proliferation
The ubiquitin E3 ligase CHIP promotes proteasomal degradation of the serine/threonine protein kinase PINK1 during staurosporine-induced cell death
Cytosolic PTEN-induced Putative Kinase 1 Is Stabilized by the NF-κB Pathway and Promotes Non-selective Mitophagy
STAT5 is an ambivalent regulator of neutrophil homeostasis
A novel Ca2+/calmodulin antagonist HBC inhibits angiogenesis and down-regulates hypoxia-inducible factor
The conserved WRPW motif of Hes6 mediates proteasomal degradation
UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131
Small ubiquitin-like modifier (SUMO) modification of zinc finger protein 131 potentiates its negative effect on estrogen signaling
Ubiquitin-specific protease 22 (USP22) positively regulates RCAN1 protein levels through RCAN1 de-ubiquitination
Deubiquitinating enzyme USP22 positively regulates c-Myc stability and tumorigenic activity in mammalian and breast cancer cells
Suppression of Nkx3.2 by phosphatidylinositol-3-kinase signaling regulates cartilage development by modulating chondrocyte hypertrophy
VBP1 represses cancer metastasis by enhancing HIF-1α degradation induced by pVHL
S100A11 is involved in the regulation of the stability of cell cycle regulator p21(CIP1/WAF1) in human keratinocyte HaCaT cells
3-nitropropionic Acid 투여 후 마우스 선조체에서 Apurinic/Apyrimidinic Endonuclease 의 발현과신경세포고사
Hsp90 rescues PTK6 from proteasomal degradation in breast cancer cells
Cell type-dependent activities of the ubiquitin-proteasome system and selective neurodegeneration
Effect of human papillomavirus-16 infection on CD8+ T-cell recognition of a wild-type sequence p53264-272 peptide in patients with squamous cell carcinoma of the head and neck
USP7 controls Chk1 protein stability by direct deubiquitination
Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkin
Identification of repurposed small molecule drugs for chordoma therapy
TORC1 controls degradation of the transcription factor Stp1, a key effector of the SPS amino-acid-sensing pathway in Saccharomyces cerevisiae
Lysine residues Lys-19 and Lys-49 of beta-catenin regulate its levels and function in T cell factor transcriptional activation and neoplastic transformation
Escherichia coli type 1 pili trigger late IL-8 production by neutrophil-like differentiated PLB-985 cells through a Src family kinase- and MAPK-dependent mechanism
Ubiquitin ligase E6AP mediates nonproteolytic polyubiquitylation of β-catenin independent of the E6 oncoprotein
Histone deacetylase 3 promotes RCAN1 stability and nuclear translocation
Kif4 interacts with EB1 and stabilizes microtubules downstream of Rho-mDia in migrating fibroblasts
Covalent NEDD8 conjugation increases RCAN1 protein stability and potentiates its inhibitory action on calcineurin
Autophagic-lysosomal inhibition compromises ubiquitin-proteasome system performance in a p62 dependent manner in cardiomyocytes
Proteasome inhibition promotes Parkin-Ubc13 interaction and lysine 63-linked ubiquitination
Ubiquitin-associated (UBA) domain in human Fas associated factor 1 inhibits tumor formation by promoting Hsp70 degradation
Human Polycomb protein 2 promotes α-synuclein aggregate formation through covalent SUMOylation
FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis
Up-regulation of human bradykinin B1 receptor by secreted components of Pseudomonas aeruginosa via a NF-κB pathway in epithelial cells
SRG3/mBAF155 stabilizes the SWI/SNF-like BAF complex by blocking CHFR mediated ubiquitination and degradation of its major components
Atorvastatin prevents endothelial dysfunction in high glucose condition through Skp2-mediated degradation of FOXO1 and ICAM-1
A novel Pseudomonas aeruginosa-derived effector cooperates with flagella to mediate the upregulation of interleukin 8 in human epithelial cells
Proteasomes regulate hepatitis B virus replication by degradation of viral core-related proteins in a two-step manner
Involvement of protein synthesis and degradation in long-term potentiation of Schaffer collateral CA1 synapses
Up-regulation of bradykinin B2 receptor by Pseudomonas aeruginosa via the NF-κB pathway
Studies on the epigenetic and transcriptional regulation of autophagy
Comparative gene expression profiling of benign and malignant lesions reveals candidate therapeutic compounds for leiomyosarcoma
Hrd1 Partners In Endoplasmic Reticulum-Associated Degradation
Studies on the Epigenetic and Transcriptional Regulation of LSD1 in Inflammatory Response
Counter-Regulation of Human Cd4+ T Helper 2 Lymphocyte Development and Stability by Type I Interferon
Studies on the role of SRG3 for the stability of the SWI/SNF chromatin remodeling complex and the function of BAP1 during thymocyte development
Pellino 1 Communicates Intercellular Signaling in Chronic Skin Inflammatory Microenvironment
The role of Kif4 in microtubule stabilization
Targeting Tau Degradation by Small Molecule Inhibitors for Treatment of Tauopathies
Novel functions of Rad52 in chromosome bi-orientation during mitosis
Oxidative stress-induced cyclin D1 depletion and its role in cell cycle processing
Contributions of PTEN to PML-IV-Mediated Cellular Senescence and Free Fatty Acid-Induced Oxidative Stress
Role of the proteasome in the downregulation of transcription factors NFκB and C/EBP in macrophages from tumor hosts
Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101
Hsp90 inhibitor partially corrects nephrogenic diabetes insipidus in a conditional knock-in mouse model of aquaporin-2 mutation
GCA links TRAF6-ULK1-dependent autophagy activation in resistant chronic myeloid leukemia
Synaptic control of DNA-methylation involves activity-dependent degradation of DNMT3a1 in the nucleus
Structural basis for recognition of the tumor suppressor protein PTPN14 by the oncoprotein E7 of human papillomavirus
HCMV-encoded US7 and US8 act as antagonists of innate immunity by distinctively targeting TLR-signaling pathways
We found other products you might like!
To Top