Okadaic Acid, Free Form

SKU
O-1024
  • CAS:78111-17-8
  • Formula:C44H68O13
  • MW:805 Da
  • Appearance:White crystalline solid or clear, colorless film
  • Purity:>98%

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Product Name Qty
Okadaic acid, Prorocentrum concavum, High Purity
100 ug
$200.00
Okadaic acid, Prorocentrum concavum, High Purity
1 mg
$1,100.00
Okadaic acid, Prorocentrum concavum, High Purity
50 ug
$125.00

Description

Potent inhibitor of protein phosphatases, especially protein phosphatases 1 and 2 classes. Also used as a tumor promoter. CD45 regulates retention, motility, and numbers of hematopoietic progenitors, and affects osteoclast remodeling of metaphyseal trabecules. Isolated from Prorocentrum concavum. Okadaic acid is a toxin that accumulates in bivalves and causes diarrheal shellfish poisoning.

More Information
Alternate Name/Synonyms
9,10-Deepithio-9,10-didehydroacanthifolicin; halochondrine A; OA; Acanthifolicin; 35-demethyl DTX1; NSC 677083
SKU
O-1024
CAS #
78111-17-8
Chemical Name
(2R)-3-[(2S,6R,8S,11R)-2-[(E,2R)-4-[(2S,2'R,4R,4aS,6R,8aR)-4-hydroxy-2-[(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5'-oxolane]-2'-yl]but-3-en-2-yl]-11-hyd
Chemical Formula
C44H68O13
Molecular Weight
805 Da
Appearance
White crystalline solid or clear, colorless film
Purity
>98%
Solubility
Soluble in DMSO or ethanol.
Melting Point
164-166°C
Storage Temp
Store at or below -20 ÂșC
THERAPEUTIC AREA
Not Available
USE
Biochemical tool as tumor promoter and probe of cellular regulation. Tumor promoting cytotoxin associated with diuretic seafood poisoning.
Merck Index
Merck Index: 13.6891.2001
MDL NUMBER
MFCD00083455
CHEMACX
X1000293-6
INCHI
InChI=1S/C44H68O13/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,6H3,(H,48,49)/b10-9+/t26-,27-,28+,30+,31+,32+,33-,34+,35-,36-,37+,38+,39-,41-,42+,43-,44-/m1/s1
SMILES
C[C@@H]1CC[C@]2(CCCCO2)O[C@@H]1[C@@H](C)C[C@@H]([C@@H]3C(=C)[C@H]([C@H]4[C@H](O3)CC[C@]5(O4)CC[C@@H](O5)/C=C/[C@@H](C)[C@@H]6CC(=C[C@@]7(O6)[C@@H](CC[C@H](O7)C[C@](C)(C(=O)O)O)O)C)O)O
RTECS
AA8227800
UN #'S
UN 3462
PACKING GROUP
I
Handling
Avoid contact with skin, eyes and clothing; material may be an irritant.
Citations
CD45 regulates retention, motility, and numbers of hematopoietic progenitors, and affects osteoclast remodeling of metaphyseal trabecules Shoham Shivtiel, Orit Kollet, Kfir Lapid, Amir Schajnovitz, Polina Goichberg, Alexander Kalinkovich, Elias Shezen, Melania Tesio, Neta Netzer, Isabelle Petit, Amnon Sharir, and Tsvee Lapidot J. Exp. Med., Sep 2008; 205: 2381 - 2395.
Citations_Hyperlink
http://jem.rupress.org/cgi/reprint/205/10/2381
Certificate of Analysis 1
Certificate of Analysis 2
GHS PICTOGRAMS
Handling Avoid contact with skin, eyes and clothing; material may be an irritant.
UN #'S UN 3462
Packing Group I
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