Folimycin; TAN 1323B
80890-47-7
866.1
C46H75NO14
DMSO
-20°C
Concanamycin A (isolated from Streptomyces sp.) is an antibiotic and a highly potent and specific cell-permeable inhibitor of V-ATPases that allows to rapidly inactivate this proton pump in living cells. Concanamycin A is more potent specific inhibitor than Bafilomycin A1. Inhibits the acidification of organelles including lysosomes and the Golgi apparatus.
Concanamycin A is reported to block cell surface expression of viral glycoproteins without affecting synthesis. Exhibits cytotoxic effects in a number of cell lines in a cell viability assay. Studies have shown that Concanamycin A can cause apoptosis in Human oral squamous carcinoma cells.
Concanamycin A can be used for viral entry studies, it inhibits syncytium formation without affecting glycoprotein synthesis.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.