Soluble in DMSO (10 mg/ml) or H2O (25 mg/ml)
A nucleoside analog of deoxycytidine used in chemotherapy to treat various types of cancer. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.
Research or further manufacturing use only, not for food or drug use.