Gamcitabine; Gemcitera
122111-03-9
299.66
C9H11F2N3O4•HCl
DMSO, Water
-20°C
Gemcitabine hydrochloride is a nucleoside analog of deoxycytidine used in chemotherapy to treat various types of cancer. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP).
dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.